Chromosome abnormalities in sperm from infertile men with asthenoteratozoospermia

Rositsa Hristova, Evelyn Ko, Calvin Greene, Alfred Rademaker, Judy Chernos, Renée Martin*

*Corresponding author for this work

Research output: Contribution to journalArticle

55 Scopus citations

Abstract

Research over the past few years has clearly demonstrated that infertile men have an increased frequency of chromosome abnormalities in their sperm. These studies have been further corroborated by an increased frequency of chromosome abnormalities in newborns and fetuses from pregnancies established by intracytoplasmic sperm injection. Most studies have considered men with any type of infertility. However, it is possible that some types of infertility have an increased risk of sperm chromosome abnormalities, whereas others do not. We studied 10 men with a specific type of infertility, asthenozoospermia (poor motility), by multicolor fluorescence in situ hybridization analysis to determine whether they had an increased frequency of disomy for chromosomes 13, 21, XX, YY, and XY, as well as diploidy. The patients ranged in age from 28 to 42 yr (mean 34.1 yr); they were compared with 18 normal control donors whose ages ranged from 23 to 58 yr (mean 35.6 yr). A total of 201 416 sperm were analyzed in the men with asthenozoospermia, with a minimum of 10 000 sperm analyzed per chromosome probe per donor. There was a significant increase in the frequency of disomy in men with asthenozoospermia compared with controls for chromosomes 13 and XX. Thus, this study indicates that infertile men with poorly motile sperm but normal concentration have a significantly increased frequency of sperm chromosome abnormalities.

Original languageEnglish (US)
Pages (from-to)1781-1783
Number of pages3
JournalBiology of Reproduction
Volume66
Issue number6
DOIs
StatePublished - Jan 1 2002

Keywords

  • Assisted reproductive technology
  • Sperm
  • Sperm motility and transport
  • Spermatogenesis

ASJC Scopus subject areas

  • Cell Biology

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