@article{03842d390c0b4a6caa8bb106183a3f80,
title = "Chromosome-scale selective sweeps shape Caenorhabditis elegans genomic diversity",
abstract = "The nematode Caenorhabditis elegans is central to research in molecular, cell and developmental biology, but nearly all of this research has been conducted on a single strain of C. elegans. Little is known about the population genomic and evolutionary history of this species. We characterized C. elegans genetic variation using high-throughput selective sequencing of a worldwide collection of 200 wild strains and identified 41,188 SNPs. Notably, C. elegans genome variation is dominated by a set of commonly shared haplotypes on four of its six chromosomes, each spanning many megabases. Population genetic modeling showed that this pattern was generated by chromosome-scale selective sweeps that have reduced variation worldwide; at least one of these sweeps probably occurred in the last few hundred years. These sweeps, which we hypothesize to be a result of human activity, have drastically reshaped the global C. elegans population in the recent past.",
author = "Andersen, {Erik C.} and Gerke, {Justin P.} and Shapiro, {Joshua A.} and Crissman, {Jonathan R.} and Rajarshi Ghosh and Bloom, {Joshua S.} and F{\'e}lix, {Marie Anne} and Leonid Kruglyak",
note = "Funding Information: the Caenorhabditis Genetics Center. We also thank the Waksman Genomics Core Facility and the Lewis-Sigler Institute Microarray Facility for the Illumina sequencing. We also thank P. Andolfatto, M. Rockman, H. Seidel, R. Tanny and the members of the Kruglyak laboratory for helpful discussions and comments on the manuscript. This work was supported by a US National Institutes of Health (NIH) Ruth L. Kirschstein National Research Service Award (E.C.A.), the Merck Fellowship of the Life Science Research Foundation (J.P.G.), a National Science Foundation graduate research fellowship (J.S.B.), a James S. McDonnell Foundation Centennial Fellowship, the Howard Hughes Medical Institute and NIH grants R01-HG004321, R37-MH59520 (L.K.) and P50-GM071508 to the Center for Quantitative Biology at the Lewis-Sigler Institute of Princeton University.",
year = "2012",
month = mar,
doi = "10.1038/ng.1050",
language = "English (US)",
volume = "44",
pages = "285--290",
journal = "Nature Genetics",
issn = "1061-4036",
publisher = "Nature Publishing Group",
number = "3",
}