Chronic anterior uveitis in common variable immunodeficiency

Purpose: To describe patients with uveitis and common variable immunodeficiency (CVID). Design: Retrospective observational case series. Methods: Retrospective review of patients with uveitis and CVID, specifically focusing on clinical presentation and treatment. Results: Three patients with CVID and uveitis were identified. All patients had chronic anterior uveitis. Two required systemic immunosuppression to control uveitis, with one of these patients relapsing after discontinuation of immunoglobulin therapy. One improved on topical steroid therapy; however, follow-up on this patient did not extend beyond 4 months. Conclusions: CVID can be associated with chronic anterior uveitis. Patients presenting with uveitis should be questioned about frequent infections and autoimmune disorders as part of the uveitis evaluation.