Chronic cutaneous granulomatous dermopathy: Morphologic and serologic evaluation, differential diagnosis and pharmacologic control1

Kris G. McGrath, Henry H. Roenigk, John J. Phair, Roy Patterson*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

We report on a syndrome of disfiguring lower extremity cutaneous lesions of 6 years duration. Previous medical evaluations included 5 skin biopsies and several therapeutic regimens which did not alter the course of illness. The histologic interpretations of skin biopsies included panniculitis, papulonecrosis, and granuloma. One biopsy was interpreted as a localized cutaneous vasculitis with a wedge-shaped infarct. Infectious, collagen vascular, and factitious etiologies could not be demonstrated to explain the patient's lesions. The Chicago Dermatological Society included in their differential diagnosis bacterial allergy, including the tuberculoid reaction. Mycobacterium tuberculosis as the etiology was dismissed by negative cultures, histologic staining and failure of response to antituberculous therapy. Our report includes a series of immunologic tests that might be consistent with but do not definitively establish a bacterial hypersensitivity reaction to explain this patient's skin lesions. Despite a lack of proven etiology dramatic improvement occurred with corticosteroid therapy.

Original languageEnglish (US)
Pages (from-to)318-323
Number of pages6
JournalInternational archives of allergy and immunology
Volume76
Issue number4
DOIs
StatePublished - 1985

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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