Chronic heliodermatitis: A morphologic evaluation of chronic actinic dermal damage with emphasis on the role of mast cells

Robert M. Lavker*, Albert M. Kligman

*Corresponding author for this work

Research output: Contribution to journalArticle

164 Scopus citations

Abstract

Descriptions of actinically damaged human dermis have focused on the late stages of elastotic degeneration. This has diverted attention from preceeding events, which are important for understanding the sequence of pathologic changes that culminate in the deranged fibrous structures of elastotic dermis. We studied specimens from the back of the necks (exposed) and inner arms (unexposed) of 24 individuals, aged 35-84 yrs by light and transmission electron microscopy. Intense sunlight exposure was common to all. A previously undescribed finding was the presence of a perivenular, histiocytic-lymphocytic infiltrate in which numerous mast cells, often in close apposition to fibroblasts, were observed. We have termed this "chronic heliodermatitis". We postulate that mast cell-derived mediators in conjunction with enzymes released by the infiltrating cells lead to breakdown of elastic and collagen fibers.

Original languageEnglish (US)
Pages (from-to)325-330
Number of pages6
JournalJournal of Investigative Dermatology
Volume90
Issue number3
DOIs
StatePublished - Jan 1 1988

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Dermatology
  • Cell Biology

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