Chronic high-dosage androgen administration to ovulatory women does not alter adrenocortical steroidogenesis

W. Futterweit*, G. Green, N. Tarlin, A. Dunaif

*Corresponding author for this work

Research output: Contribution to journalArticle

8 Scopus citations


Objective: To evaluate the role of chronic long-term exogenous androgen administration to normal ovulatory women on adrenal steroidogenesis. Design: Prospective study of four consecutive female-to-male transsexuals before and during chronic testosterone (T) therapy. Setting: Clinical Research Center of the Mount Sinai Medical Center. Patients: Four female-to-male transsexuals were studied before and during 6 to 12 months of chronic T enanthate therapy for desired virilization. All four subjects were ovulatory before treatment. Adrenocorticotropic hormone (ACTH) testing was performed before, and 6 and 12 months of androgen therapy and various adrenal androgens as well as precursor:product pairs were evaluated as an index of specific adrenocortical biosynthetic defects. Results: Baseline and 1 hour after 0.25 mg ACTH intravenously, adrenal androgen levels as well as adrenal precursor/product pairs demonstrated no difference before and during chronic T treatment. Studies included determinations of plasma 17-hydroxypregnenolone, 17- hydroxyprogesterone, dehydroepiandrosterone, androstenedione, 11- deoxycortisol, and cortisol. Conclusion: It is concluded that chronic hypertestosteronemia does not alter adrenal steroidogenesis.

Original languageEnglish (US)
Pages (from-to)124-128
Number of pages5
JournalFertility and Sterility
Issue number1
StatePublished - 1992


  • Adrenocorticotropic hormone stimulation test
  • Cortrosyn stimulation test
  • adrenal biosynthesis
  • adrenal steroidogenesis
  • androgen therapy
  • testosterone therapy

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology

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