Chronic intestinal pseudoobstruction in young children

S. Anuras*, F. A. Mitros, R. T. Soper, K. C. Pringle, B. V. Maves, M. K. Younoszai, E. A. Franken, P. Whitington

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

39 Scopus citations

Abstract

We studied 8 young children (4 boys and 4 girls) with chronic intestinal pseudoobstruction. Intestinal pseudoobstruction, recurrent urinary tract infections, and dysuria occurred between the ages of a few weeks to 5 yr old. All had marked dilatation of the entire gastrointestinal tract distal to the esophagus, and megacystis. Conventional pathologic examinations of the full-thickness specimens of the gastrointestinal tract were normal in 5 and abnormal in 2 patients. The abnormalities included increased fibrosis and lipofuscin pigment in the smooth muscle cells. Myenteric plexus examination, using the Smith's method in 2 patients, was normal. Biopsy specimens from urinary bladders examined in 3 patients revealed separation of individual smooth muscle cells by collagen fibers. Intestinal manometric studies performed in 3 patients showed only weak and infrequent contractions during fasting and after feeding. Severe and extensive dysfunction of the gastrointestinal and urinary tracts with relatively normal histologic appearance are typical for these children.

Original languageEnglish (US)
Pages (from-to)62-70
Number of pages9
JournalGastroenterology
Volume91
Issue number1
DOIs
StatePublished - Jul 1986

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

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