TY - JOUR
T1 - Chronic lithium treatment has antioxidant properties but does not prevent oxidative damage induced by chronic variate stress
AU - De Vasconcellos, Ana Paula Santana
AU - Nieto, Fabiane Battistela
AU - Crema, Leonardo Machado
AU - Diehl, Luisa Amália
AU - De Almeida, Lúcia Maria
AU - Prediger, Martha Elisa
AU - Da Rocha, Elizabete Rocha
AU - Dalmaz, Carla
N1 - Funding Information:
Acknowledgment Supported by Conselho Nacional de Desen-volvimento Científico e Tecnológico, CNPq.
PY - 2006/9
Y1 - 2006/9
N2 - This study evaluated the effects of chronic stress and lithium treatments on oxidative stress parameters in hippocampus, hypothalamus, and frontal cortex. Adult male Wistar rats were divided into two groups: control and submitted to chronic variate stress, and subdivided into treated or not with LiCl. After 40 days, rats were killed, and lipoperoxidation, production free radicals, total antioxidant reactivity (TAR) levels, and superoxide dismutase (SOD) and glutathione peroxidase (GPx) activities were evaluated. The results showed that stress increased lipoperoxidation and that lithium decreased free radicals production in hippocampus; both treatments increased TAR. In hypothalamus, lithium increased TAR and no effect was observed in the frontal cortex. Stress increased SOD activity in hippocampus; while lithium increased GPx in hippocampus and SOD in hypothalamus. We concluded that lithium presented antioxidant properties, but is not able to prevent oxidative damage induced by chronic variate stress.
AB - This study evaluated the effects of chronic stress and lithium treatments on oxidative stress parameters in hippocampus, hypothalamus, and frontal cortex. Adult male Wistar rats were divided into two groups: control and submitted to chronic variate stress, and subdivided into treated or not with LiCl. After 40 days, rats were killed, and lipoperoxidation, production free radicals, total antioxidant reactivity (TAR) levels, and superoxide dismutase (SOD) and glutathione peroxidase (GPx) activities were evaluated. The results showed that stress increased lipoperoxidation and that lithium decreased free radicals production in hippocampus; both treatments increased TAR. In hypothalamus, lithium increased TAR and no effect was observed in the frontal cortex. Stress increased SOD activity in hippocampus; while lithium increased GPx in hippocampus and SOD in hypothalamus. We concluded that lithium presented antioxidant properties, but is not able to prevent oxidative damage induced by chronic variate stress.
KW - Antioxidant enzymes
KW - Chronic variate stress
KW - Free radicals
KW - GPx
KW - Lipoperoxidation
KW - Lithium
KW - Oxidative stress
KW - SOD
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U2 - 10.1007/s11064-006-9139-2
DO - 10.1007/s11064-006-9139-2
M3 - Article
C2 - 16944317
AN - SCOPUS:33748589993
SN - 0364-3190
VL - 31
SP - 1141
EP - 1151
JO - Neurochemical Research
JF - Neurochemical Research
IS - 9
ER -