Chronic lithium treatment has antioxidant properties but does not prevent oxidative damage induced by chronic variate stress

Ana Paula Santana De Vasconcellos*, Fabiane Battistela Nieto, Leonardo Machado Crema, Luisa Amália Diehl, Lúcia Maria De Almeida, Martha Elisa Prediger, Elizabete Rocha Da Rocha, Carla Dalmaz

*Corresponding author for this work

Research output: Contribution to journalArticle

41 Scopus citations

Abstract

This study evaluated the effects of chronic stress and lithium treatments on oxidative stress parameters in hippocampus, hypothalamus, and frontal cortex. Adult male Wistar rats were divided into two groups: control and submitted to chronic variate stress, and subdivided into treated or not with LiCl. After 40 days, rats were killed, and lipoperoxidation, production free radicals, total antioxidant reactivity (TAR) levels, and superoxide dismutase (SOD) and glutathione peroxidase (GPx) activities were evaluated. The results showed that stress increased lipoperoxidation and that lithium decreased free radicals production in hippocampus; both treatments increased TAR. In hypothalamus, lithium increased TAR and no effect was observed in the frontal cortex. Stress increased SOD activity in hippocampus; while lithium increased GPx in hippocampus and SOD in hypothalamus. We concluded that lithium presented antioxidant properties, but is not able to prevent oxidative damage induced by chronic variate stress.

Original languageEnglish (US)
Pages (from-to)1141-1151
Number of pages11
JournalNeurochemical Research
Volume31
Issue number9
DOIs
StatePublished - Sep 1 2006

Keywords

  • Antioxidant enzymes
  • Chronic variate stress
  • Free radicals
  • GPx
  • Lipoperoxidation
  • Lithium
  • Oxidative stress
  • SOD

ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience

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    De Vasconcellos, A. P. S., Nieto, F. B., Crema, L. M., Diehl, L. A., De Almeida, L. M., Prediger, M. E., Da Rocha, E. R., & Dalmaz, C. (2006). Chronic lithium treatment has antioxidant properties but does not prevent oxidative damage induced by chronic variate stress. Neurochemical Research, 31(9), 1141-1151. https://doi.org/10.1007/s11064-006-9139-2