Chronic Low Dose Prostaglandin and Neonatal Heart Block

Safwat A. Aly; Sawsan M. Awad; Raid Abdulla; Suhaib Kazmouz; Hoang H. Nguyen

doi:10.1007/s00246-017-1633-6

Chronic Low Dose Prostaglandin and Neonatal Heart Block

Safwat A. Aly^*, Sawsan M. Awad, Raid Abdulla, Suhaib Kazmouz, Hoang H. Nguyen

^*Corresponding author for this work

Pediatrics

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Long-term prostaglandin use is commonly associated with side effects such as cortical proliferation of the bones, hypertrophic pyloric stenosis, and soft tissue swelling of the extremities. We report a neonate with critical coarctation of the aorta, who developed second and third degree atrioventricular blocks associated with prolonged prostaglandin E1 (PGE1) infusion. Interestingly, these conduction blocks only occurred at low PGE1 dose. The rhythm disturbances resolved promptly with the discontinuation of PGE1 following surgical repair.

Original language	English (US)
Pages (from-to)	1515-1518
Number of pages	4
Journal	Pediatric cardiology
Volume	38
Issue number	7
DOIs	https://doi.org/10.1007/s00246-017-1633-6
State	Published - Oct 1 2017

Keywords

Heart Block
PGE1
Prostaglandin

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Cardiology and Cardiovascular Medicine

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10.1007/s00246-017-1633-6

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AU - Kazmouz, Suhaib

AU - Nguyen, Hoang H.

PY - 2017/10/1

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N2 - Long-term prostaglandin use is commonly associated with side effects such as cortical proliferation of the bones, hypertrophic pyloric stenosis, and soft tissue swelling of the extremities. We report a neonate with critical coarctation of the aorta, who developed second and third degree atrioventricular blocks associated with prolonged prostaglandin E1 (PGE1) infusion. Interestingly, these conduction blocks only occurred at low PGE1 dose. The rhythm disturbances resolved promptly with the discontinuation of PGE1 following surgical repair.

AB - Long-term prostaglandin use is commonly associated with side effects such as cortical proliferation of the bones, hypertrophic pyloric stenosis, and soft tissue swelling of the extremities. We report a neonate with critical coarctation of the aorta, who developed second and third degree atrioventricular blocks associated with prolonged prostaglandin E1 (PGE1) infusion. Interestingly, these conduction blocks only occurred at low PGE1 dose. The rhythm disturbances resolved promptly with the discontinuation of PGE1 following surgical repair.

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KW - PGE1

KW - Prostaglandin

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Chronic Low Dose Prostaglandin and Neonatal Heart Block

Abstract

Keywords

ASJC Scopus subject areas

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