Chronic lymphocytic leukemia in association with a second lymphoproliferative disorder

Response to chemotherapy in two cases

Leo I. Gordon*, William Hrushesky, Martin M. Oken, Neil E. Kay, Robert E. Rydell

*Corresponding author for this work

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The development of either histiocytic lymphoma or Hodgkin disease in association with pre‐existing chronic lymphocytic leukemia has been described in the literature as a terminal event. We describe two patients in whom the diagnosis of a second malignant lymphoma was made during life and who achieved objective clinical response after a change in therapy to a more aggressive combination of drugs. We conclude that patients with chronic lymphocytic leukemia who have had a sudden change in their clinical course should have thorough reevaluation, looking specifically for the development of a second lymphoproliferative disorder. If this is discovered, more aggressive therapy should be initiated.

Original languageEnglish (US)
Pages (from-to)111-116
Number of pages6
JournalMedical and Pediatric Oncology
Volume7
Issue number2
DOIs
StatePublished - Jan 1 1979

Fingerprint

Lymphoproliferative Disorders
B-Cell Chronic Lymphocytic Leukemia
Drug Therapy
Lymphoma, Large B-Cell, Diffuse
Drug Combinations
Hodgkin Disease
Lymphoma
Therapeutics

Keywords

  • Richters syndrome
  • leukemia
  • lymphoma

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Oncology
  • Cancer Research

Cite this

Gordon, Leo I. ; Hrushesky, William ; Oken, Martin M. ; Kay, Neil E. ; Rydell, Robert E. / Chronic lymphocytic leukemia in association with a second lymphoproliferative disorder : Response to chemotherapy in two cases. In: Medical and Pediatric Oncology. 1979 ; Vol. 7, No. 2. pp. 111-116.
@article{6c01ad7253c64009a672dea101542a9f,
title = "Chronic lymphocytic leukemia in association with a second lymphoproliferative disorder: Response to chemotherapy in two cases",
abstract = "The development of either histiocytic lymphoma or Hodgkin disease in association with pre‐existing chronic lymphocytic leukemia has been described in the literature as a terminal event. We describe two patients in whom the diagnosis of a second malignant lymphoma was made during life and who achieved objective clinical response after a change in therapy to a more aggressive combination of drugs. We conclude that patients with chronic lymphocytic leukemia who have had a sudden change in their clinical course should have thorough reevaluation, looking specifically for the development of a second lymphoproliferative disorder. If this is discovered, more aggressive therapy should be initiated.",
keywords = "Richters syndrome, leukemia, lymphoma",
author = "Gordon, {Leo I.} and William Hrushesky and Oken, {Martin M.} and Kay, {Neil E.} and Rydell, {Robert E.}",
year = "1979",
month = "1",
day = "1",
doi = "10.1002/mpo.2950070203",
language = "English (US)",
volume = "7",
pages = "111--116",
journal = "Pediatric Blood and Cancer",
issn = "1545-5009",
publisher = "Wiley-Liss Inc.",
number = "2",

}

Chronic lymphocytic leukemia in association with a second lymphoproliferative disorder : Response to chemotherapy in two cases. / Gordon, Leo I.; Hrushesky, William; Oken, Martin M.; Kay, Neil E.; Rydell, Robert E.

In: Medical and Pediatric Oncology, Vol. 7, No. 2, 01.01.1979, p. 111-116.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Chronic lymphocytic leukemia in association with a second lymphoproliferative disorder

T2 - Response to chemotherapy in two cases

AU - Gordon, Leo I.

AU - Hrushesky, William

AU - Oken, Martin M.

AU - Kay, Neil E.

AU - Rydell, Robert E.

PY - 1979/1/1

Y1 - 1979/1/1

N2 - The development of either histiocytic lymphoma or Hodgkin disease in association with pre‐existing chronic lymphocytic leukemia has been described in the literature as a terminal event. We describe two patients in whom the diagnosis of a second malignant lymphoma was made during life and who achieved objective clinical response after a change in therapy to a more aggressive combination of drugs. We conclude that patients with chronic lymphocytic leukemia who have had a sudden change in their clinical course should have thorough reevaluation, looking specifically for the development of a second lymphoproliferative disorder. If this is discovered, more aggressive therapy should be initiated.

AB - The development of either histiocytic lymphoma or Hodgkin disease in association with pre‐existing chronic lymphocytic leukemia has been described in the literature as a terminal event. We describe two patients in whom the diagnosis of a second malignant lymphoma was made during life and who achieved objective clinical response after a change in therapy to a more aggressive combination of drugs. We conclude that patients with chronic lymphocytic leukemia who have had a sudden change in their clinical course should have thorough reevaluation, looking specifically for the development of a second lymphoproliferative disorder. If this is discovered, more aggressive therapy should be initiated.

KW - Richters syndrome

KW - leukemia

KW - lymphoma

UR - http://www.scopus.com/inward/record.url?scp=0018736532&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018736532&partnerID=8YFLogxK

U2 - 10.1002/mpo.2950070203

DO - 10.1002/mpo.2950070203

M3 - Article

VL - 7

SP - 111

EP - 116

JO - Pediatric Blood and Cancer

JF - Pediatric Blood and Cancer

SN - 1545-5009

IS - 2

ER -