Chronic microsensors for longitudinal, subsecond dopamine detection in behaving animals

Jeremy J. Clark, Stefan G. Sandberg, Matthew J. Wanat, Jerylin O. Gan, Eric A. Horne, Andrew S. Hart, Christina A. Akers, Jones Griffith Parker, Ingo Willuhn, Vicente Martinez, Scott B. Evans, Nephi Stella, Paul E.M. Phillips

Research output: Contribution to journalArticlepeer-review

232 Scopus citations


Neurotransmission operates on a millisecond timescale but is changed by normal experience or neuropathology over days to months. Despite the importance of long-term neurotransmitter dynamics, no technique exists to track these changes in a subject from day to day over extended periods of time. Here we describe and characterize a microsensor that can detect the neurotransmitter dopamine with subsecond temporal resolution over months in vivo in rats and mice.

Original languageEnglish (US)
Pages (from-to)126-129
Number of pages4
JournalNature Methods
Issue number2
StatePublished - Feb 2010

ASJC Scopus subject areas

  • Biotechnology
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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