Chronic myeloid leukemia in children: Clinical findings, management, and unanswered questions

Nobuko Hijiya*, Frederic Millot, Meinolf Suttorp

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

34 Scopus citations

Abstract

Chronic myelogenous leukemia (CML) is a rare disease in children. There is little evidence of biological differences between CML in children and adults, although host factors are different. Children develop distinct morbidities related to the off-target effects of tyrosine kinase inhibitors. The goal of treatment in children should be cure rather than suppression of disease, which can be the treatment goal for many older adults. This article reviews data from the literature on the treatment of CML, discusses the issues that are unique to CML in children, and recommends management that takes these issues into consideration.

Original languageEnglish (US)
Pages (from-to)107-119
Number of pages13
JournalPediatric Clinics of North America
Volume62
Issue number1
DOIs
StatePublished - Feb 1 2015

Keywords

  • BCR-ABL1
  • Chronic myeloid leukemia
  • Hematopoietic stem cell transplant
  • Tyrosine kinase inhibitor

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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