TY - JOUR
T1 - Chronic neurologic disease in Theiler's virus infection of SJL/J mice
AU - Lipton, Howard L.
AU - Dal Canto, Mauro C.
N1 - Funding Information:
In the early 1930s Theiler (1934) reported the isolation of a virus from the central nervous systems (CNS) of mice that had developed spontaneous flaccid limb para- This study was supported by National Multiple Sclerosis Society grant RG 891-B-2 and grant 1 R01 NSI3011-01 from the National Institutes of Health. Send reprint requests to H.L.L., Department of Neurology Northwestern University Medical School, 303 East Chicago Avenue, Chicago, Illinois 60611.
PY - 1976/11
Y1 - 1976/11
N2 - This study demonstrates that most SJL/J mice inoculated intracerebrally (IC) with 1000 suckling mouse 50% mean lethal doses of Theiler's encephalomyelitis virus (TMEV) develop flaccid paralysis 10-21 days after infection when there is acute spinal cord gray matter involvement (early disease). Surviving mice later develop a distinctive chronic neurologic disorder which is associated with marked mononuclear cell infiltrates and active demyelination in spinal cord white matter (late disease). Moreover, about one-fourth of infected animals only develop signs of late disease which may begin after an incubation period as long as 2 and a half months. Affected mice are less active, incontinent, and have a waddling, spastic gait. Minimal stimulation induces prolonged extensor spasms of all limbs. These late-developing manifestations of chronic TMEV infection are progressive and clinical remissions have not been observed. The effect of persistent CNS infection on general development was monitored by weekly measurement of body weight; however, the growth of chronically-infected mice was found to parallel that of control animals.
AB - This study demonstrates that most SJL/J mice inoculated intracerebrally (IC) with 1000 suckling mouse 50% mean lethal doses of Theiler's encephalomyelitis virus (TMEV) develop flaccid paralysis 10-21 days after infection when there is acute spinal cord gray matter involvement (early disease). Surviving mice later develop a distinctive chronic neurologic disorder which is associated with marked mononuclear cell infiltrates and active demyelination in spinal cord white matter (late disease). Moreover, about one-fourth of infected animals only develop signs of late disease which may begin after an incubation period as long as 2 and a half months. Affected mice are less active, incontinent, and have a waddling, spastic gait. Minimal stimulation induces prolonged extensor spasms of all limbs. These late-developing manifestations of chronic TMEV infection are progressive and clinical remissions have not been observed. The effect of persistent CNS infection on general development was monitored by weekly measurement of body weight; however, the growth of chronically-infected mice was found to parallel that of control animals.
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U2 - 10.1016/0022-510X(76)90267-7
DO - 10.1016/0022-510X(76)90267-7
M3 - Article
C2 - 978224
AN - SCOPUS:0017085526
SN - 0022-510X
VL - 30
SP - 201
EP - 207
JO - Journal of the Neurological Sciences
JF - Journal of the Neurological Sciences
IS - 1
ER -