Chronic neuropathic pain-like behavior and brain-borne IL-1β

Adriana del Rey*, A. Vania Apkarian, Marco Martina, Hugo O. Besedovsky

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

39 Scopus citations


Neuropathic pain in animals results in increased IL-1β expression in the damaged nerve, the dorsal root ganglia, and the spinal cord. Here, we discuss our results showing that this cytokine is also overexpressed at supraspinal brain regions, in particular in the contralateral side of the hippocampus and prefrontal cortex and in the brainstem, in rats with neuropathic pain-like behavior. We show that neuropathic pain degree and development depend on the specific nerve injury model and rat strain studied, and that there is a correlation between hippocampal IL-1β expression and tactile sensitivity. Furthermore, the correlations between hippocampal IL-1β and IL-1ra or IL-6 observed in control animals, are disrupted in rats with increased pain sensitivity. The lateralization of increased cytokine expression indicates that this alteration may reflect nociception. The potential functional consequences of increased IL-1β expression in the brain during neuropathic pain are discussed.

Original languageEnglish (US)
Pages (from-to)101-107
Number of pages7
JournalAnnals of the New York Academy of Sciences
Issue number1
StatePublished - Jul 2012


  • Chronic pain
  • Hippocampus
  • Interleukin-1
  • Lateralization

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science


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