Chronic opiate treatment does not modify α2-adrenergic receptors in rat cerebral cortex, kidney and in the neurotumor cell line NCB20

Lucia M. Vicentini, Richard J. Miller*, Mark J. Robertson

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

We examined the effect of chronic opiate treatment on the α2-adrenergic receptor binding of both the agonist [3H]clonidine and the antagonist [3H]yohimbine in the cerebral cortex and kidney of rats. In addition, we demonstrated the presence of an adrenergic receptor of the α2 type on the neurotumor cells line NCB20 and used this cell line as a model for studying the interaction between the opiate and α2-adrenergic systems. In all the three above systems, chronic opiate treatment did not modify the number or the affinity of α2-adrenergic receptors.

Original languageEnglish (US)
Pages (from-to)265-270
Number of pages6
JournalEuropean Journal of Pharmacology
Volume95
Issue number3-4
DOIs
StatePublished - Nov 25 1983

Keywords

  • NCB20 cell line
  • Opiate dependence
  • Rat cerebral cortex and kidney
  • α-adrenergic receptors

ASJC Scopus subject areas

  • Pharmacology

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