Chronic Osteomyelitis caused by Staphylococcus Aureus: Controlled Clinical Trial of Nafcillin Therapy and Nafcillin-Rifampin Therapy

Carl W. Norden; Richard Bryant; Darwin Palmer; John Z. Montgomerie; Joseph Wheat; Steve M. Jones; Charles B. Bird; Alan I. Hartstein; Robert C. Moellering; Adolf W. Karchmer; Robert C. Aber; Robert Greer; Monto Ho; Allen J. Weinstein; John P. Phair; Merle A. Sande; Gerald L. Mandell; Joshua Fierer; Dale Daniel; William A. Craig; Jon T. Mader; James A. Reinarz; Chronic Staphylococcal Osteomyelitis Study Group The Chronic Staphylococcal Osteomyelitis Study Group

doi:10.1097/00007611-198608000-00008

Chronic Osteomyelitis caused by Staphylococcus Aureus: Controlled Clinical Trial of Nafcillin Therapy and Nafcillin-Rifampin Therapy

Carl W. Norden^*, Richard Bryant, Darwin Palmer, John Z. Montgomerie, Joseph Wheat, Steve M. Jones, Charles B. Bird, Alan I. Hartstein, Robert C. Moellering, Adolf W. Karchmer, Robert C. Aber, Robert Greer, Monto Ho, Allen J. Weinstein, John P. Phair, Merle A. Sande, Gerald L. Mandell, Joshua Fierer, Dale Daniel, William A. CraigJon T. Mader, James A. Reinarz, Chronic Staphylococcal Osteomyelitis Study Group The Chronic Staphylococcal Osteomyelitis Study Group

^*Corresponding author for this work

Medicine, Infectious Diseases Division

Research output: Contribution to journal › Article › peer-review

71 Scopus citations

Abstract

A controlled trial of treatment of chronic osteomyelitis caused by Staphylococcus aureus compared nafcillin alone with nafcillin plus rifampin for a six-week period. Treatment was well tolerated, the only adverse effect being mild neutropenia in four of 18 patients; no toxicity was observed from rifampin. Eight of ten patients in the combined treatment group had a favorable clinical response (with follow-up of two to four years) as compared to four of eight in the nafcillin group (P =.2). Despite the failure to show a statistically significant advantage of rifampin plus nafcillin, we conclude that the combination, along with appropriate surgery, should be chronic staphylococcal osteomyelitis.

Original language	English (US)
Pages (from-to)	947-951
Number of pages	5
Journal	Southern Medical Journal
Volume	79
Issue number	8
DOIs	https://doi.org/10.1097/00007611-198608000-00008
State	Published - Aug 1986

ASJC Scopus subject areas

General Medicine

Access to Document

10.1097/00007611-198608000-00008

Cite this

Norden, C. W., Bryant, R., Palmer, D., Montgomerie, J. Z., Wheat, J., Jones, S. M., Bird, C. B., Hartstein, A. I., Moellering, R. C., Karchmer, A. W., Aber, R. C., Greer, R., Ho, M., Weinstein, A. J., Phair, J. P., Sande, M. A., Mandell, G. L., Fierer, J., Daniel, D., ... The Chronic Staphylococcal Osteomyelitis Study Group, C. S. O. S. G. (1986). Chronic Osteomyelitis caused by Staphylococcus Aureus: Controlled Clinical Trial of Nafcillin Therapy and Nafcillin-Rifampin Therapy. Southern Medical Journal, 79(8), 947-951. https://doi.org/10.1097/00007611-198608000-00008

@article{5593b2c7b2674a4f9d9d700b62be177f,

title = "Chronic Osteomyelitis caused by Staphylococcus Aureus: Controlled Clinical Trial of Nafcillin Therapy and Nafcillin-Rifampin Therapy",

abstract = "A controlled trial of treatment of chronic osteomyelitis caused by Staphylococcus aureus compared nafcillin alone with nafcillin plus rifampin for a six-week period. Treatment was well tolerated, the only adverse effect being mild neutropenia in four of 18 patients; no toxicity was observed from rifampin. Eight of ten patients in the combined treatment group had a favorable clinical response (with follow-up of two to four years) as compared to four of eight in the nafcillin group (P =.2). Despite the failure to show a statistically significant advantage of rifampin plus nafcillin, we conclude that the combination, along with appropriate surgery, should be chronic staphylococcal osteomyelitis.",

author = "Norden, {Carl W.} and Richard Bryant and Darwin Palmer and Montgomerie, {John Z.} and Joseph Wheat and Jones, {Steve M.} and Bird, {Charles B.} and Hartstein, {Alan I.} and Moellering, {Robert C.} and Karchmer, {Adolf W.} and Aber, {Robert C.} and Robert Greer and Monto Ho and Weinstein, {Allen J.} and Phair, {John P.} and Sande, {Merle A.} and Mandell, {Gerald L.} and Joshua Fierer and Dale Daniel and Craig, {William A.} and Mader, {Jon T.} and Reinarz, {James A.} and {The Chronic Staphylococcal Osteomyelitis Study Group}, {Chronic Staphylococcal Osteomyelitis Study Group}",

year = "1986",

month = aug,

doi = "10.1097/00007611-198608000-00008",

language = "English (US)",

volume = "79",

pages = "947--951",

journal = "Southern Medical Journal",

issn = "0038-4348",

publisher = "Lippincott Williams and Wilkins",

number = "8",

}

Norden, CW, Bryant, R, Palmer, D, Montgomerie, JZ, Wheat, J, Jones, SM, Bird, CB, Hartstein, AI, Moellering, RC, Karchmer, AW, Aber, RC, Greer, R, Ho, M, Weinstein, AJ, Phair, JP, Sande, MA, Mandell, GL, Fierer, J, Daniel, D, Craig, WA, Mader, JT, Reinarz, JA & The Chronic Staphylococcal Osteomyelitis Study Group, CSOSG 1986, 'Chronic Osteomyelitis caused by Staphylococcus Aureus: Controlled Clinical Trial of Nafcillin Therapy and Nafcillin-Rifampin Therapy', Southern Medical Journal, vol. 79, no. 8, pp. 947-951. https://doi.org/10.1097/00007611-198608000-00008

TY - JOUR

T1 - Chronic Osteomyelitis caused by Staphylococcus Aureus

T2 - Controlled Clinical Trial of Nafcillin Therapy and Nafcillin-Rifampin Therapy

AU - Norden, Carl W.

AU - Bryant, Richard

AU - Palmer, Darwin

AU - Montgomerie, John Z.

AU - Wheat, Joseph

AU - Jones, Steve M.

AU - Bird, Charles B.

AU - Hartstein, Alan I.

AU - Moellering, Robert C.

AU - Karchmer, Adolf W.

AU - Aber, Robert C.

AU - Greer, Robert

AU - Ho, Monto

AU - Weinstein, Allen J.

AU - Phair, John P.

AU - Sande, Merle A.

AU - Mandell, Gerald L.

AU - Fierer, Joshua

AU - Daniel, Dale

AU - Craig, William A.

AU - Mader, Jon T.

AU - Reinarz, James A.

AU - The Chronic Staphylococcal Osteomyelitis Study Group, Chronic Staphylococcal Osteomyelitis Study Group

PY - 1986/8

Y1 - 1986/8

N2 - A controlled trial of treatment of chronic osteomyelitis caused by Staphylococcus aureus compared nafcillin alone with nafcillin plus rifampin for a six-week period. Treatment was well tolerated, the only adverse effect being mild neutropenia in four of 18 patients; no toxicity was observed from rifampin. Eight of ten patients in the combined treatment group had a favorable clinical response (with follow-up of two to four years) as compared to four of eight in the nafcillin group (P =.2). Despite the failure to show a statistically significant advantage of rifampin plus nafcillin, we conclude that the combination, along with appropriate surgery, should be chronic staphylococcal osteomyelitis.

AB - A controlled trial of treatment of chronic osteomyelitis caused by Staphylococcus aureus compared nafcillin alone with nafcillin plus rifampin for a six-week period. Treatment was well tolerated, the only adverse effect being mild neutropenia in four of 18 patients; no toxicity was observed from rifampin. Eight of ten patients in the combined treatment group had a favorable clinical response (with follow-up of two to four years) as compared to four of eight in the nafcillin group (P =.2). Despite the failure to show a statistically significant advantage of rifampin plus nafcillin, we conclude that the combination, along with appropriate surgery, should be chronic staphylococcal osteomyelitis.

UR - http://www.scopus.com/inward/record.url?scp=0022762589&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022762589&partnerID=8YFLogxK

U2 - 10.1097/00007611-198608000-00008

DO - 10.1097/00007611-198608000-00008

M3 - Article

C2 - 3526570

AN - SCOPUS:0022762589

SN - 0038-4348

VL - 79

SP - 947

EP - 951

JO - Southern Medical Journal

JF - Southern Medical Journal

IS - 8

ER -

Chronic Osteomyelitis caused by Staphylococcus Aureus: Controlled Clinical Trial of Nafcillin Therapy and Nafcillin-Rifampin Therapy

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this