Chronic pain domains and their relationship to personality, abilities, and brain networks

Camila Bonin Pinto, Byron Yip, Jannis Bielefeld, Joana Barroso, Lejian Huang, Thomas Schnitzer, A. Vania Apkarian*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Chronic pain is a multidimensional pathological state. Recent evidence suggests that specific brain properties and patients' psychological and physical traits are distorted in chronic pain patients. However, the relationship between these alterations and pain dimensions remains poorly understood. Here we first evaluated multiple dimensions of chronic pain by assessing a broad battery of pain-related questionnaire scores (23 outcomes) of 107 chronic low back pain (CBP) patients, we identified three distinct chronic pain domains: magnitude, affect & disability, and quality. Second, we investigated the pain domains relationship with measures of personality, social interaction, psychological traits, and ability traits (77 biopsy&ab outcomes). Pain magnitude (OOS r2=0.33) associated with emotional control, attention and working memory; with higher pain scores showing lower capacity to regulate and adapt behaviorally. Pain affect & disability (OOS r2=0.79) associated with anxiety, catastrophizing and social relationships dysfunction. Pain quality did not relate significantly to biopsy&ab variables. Third, we mapped these three pain domains to brain functional connectivity. Pain magnitude mainly associated with the sensorimotor and the cingulo-opercular networks (OOS r2=0.41). Pain affect & disability related to frontoparietal and default mode networks (OOS r2=0.35). Pain quality integrated sensorimotor, auditory, and cingulo-opercular networks (OOS r2=0.43). Mediation analysis could link functional connectivity and biopsy&ab models to respective pain domains. Our results provide a global overview of the complexity of chronic pain, showing how underlying distinct domains of the experience map to different biopsy&ab correlates and underlie unique brain network signatures.

Original languageEnglish (US)
JournalPain
DOIs
StateAccepted/In press - 2022

Keywords

  • Aspects of pain
  • brain functional connectivity
  • Human ability
  • NIH toolbox
  • Pain predictions
  • Personality and Character

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Anesthesiology and Pain Medicine

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