Chronic rhinosinusitis and age: Is the pathogenesis different?

Mahboobeh Mahdavinia*, Leslie C. Grammer

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

18 Scopus citations


Chronic rhinosinusitis (CRS) is a common disease with a significant impact on quality of life, which is seen across all age groups. There are differences in symptomatology, histopathology and associated diseases when comparing pediatric versus adult patients with CRS. Nasal polyposis tends to be less commonly seen in pediatric CRS compared with adults except in children with cystic fibrosis or allergic fungal rhinosinusitis. The differences in histopathology of CRS in different age groups include higher cellularity and more prominent lymphocytic infiltration in children compared with adults who tend to have a stronger eosinophilic infiltration and more prominent glandular hyperplasia. There are data supporting a stronger association of gastroesophageal reflux disease and otitis media with CRS in children compared with adults. Adenoids may play a role in pediatric, but not adult CRS. Immunodeficiencies and asthma are strongly associated with CRS in all age groups. There is a paucity of data on pathophysiology of disease on elderly CRS.

Original languageEnglish (US)
Pages (from-to)1029-1040
Number of pages12
JournalExpert Review of Anti-Infective Therapy
Issue number10
StatePublished - 2013


  • adults
  • bacteriology
  • chronic rhinosinusitis
  • elderly
  • histopathology
  • immunodeficiency
  • nasal polyps
  • pediatrics

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)
  • Virology
  • Infectious Diseases


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