Chronic rhinosinusitis and superantigens

Kristin A. Seiberling, Leslie Grammer, Robert C. Kern*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

38 Scopus citations


This article discusses the potential role of bacterial superantigens (SAgs) in chronic rhinosinusitis with nasal polyposis (CRS/NP). First, it briefly describes SAgs, focusing on how they interact with the immune system by binding to T-cell receptors (TCR) and major histocompatibility complex (MHC) class II molecules. Second, it discusses the role of SAgs in other chronic inflammatory diseases. Finally, it presents evidence for the role of SAgs in the pathogenesis and maintenance of CRS/NP focusing on current research and future considerations.

Original languageEnglish (US)
Pages (from-to)1215-1236
Number of pages22
JournalOtolaryngologic Clinics of North America
Issue number6
StatePublished - Dec 2005

ASJC Scopus subject areas

  • Otorhinolaryngology


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