TY - JOUR
T1 - Chronic Rhinosinusitis with Nasal Polyps
AU - Stevens, Whitney W.
AU - Schleimer, Robert P.
AU - Kern, Robert C.
N1 - Funding Information:
Conflicts of interest: R. P. Schleimer has received research support from the National Institutes of Health; has received consultancy fees from Intersect ENT, GlaxoSmithKline, Allakos, Aurasense, Merck, BioMarck, Sanofi, AstraZeneca/MedImmune, and Genentech; and has stock/stock options in Allakos, Aurasense, and BioMarck. The rest of the authors declare that they have no relevant conflicts of interest.
Funding Information:
This work was supported by the Chronic Rhinosinusitis Integrative Studies Program (U19-AI106683) and the Ernest Bazley Foundation.
Publisher Copyright:
© 2016 American Academy of Allergy, Asthma & Immunology
PY - 2016/7/1
Y1 - 2016/7/1
N2 - Chronic rhinosinusitis with nasal polyps (CRSwNP) is an important clinical entity diagnosed by the presence of both subjective and objective evidence of chronic sinonasal inflammation. Symptoms include anterior or posterior rhinorrhea, nasal congestion, hyposmia, and/or facial pressure or pain that last for a duration of more than 12 weeks. Nasal polyps are inflammatory lesions that project into the nasal airway, are typically bilateral, and originate from the ethmoid sinus. Males are more likely to be affected than females, but no specific genetic or environmental factors have been strongly linked to the development of this disorder to date. CRSwNP is frequently associated with asthma and allergic rhinitis, but the cellular and molecular mechanisms that contribute to the clinical symptoms are not fully understood. Defects in the sinonasal epithelial cell barrier, increased exposure to pathogenic and colonized bacteria, and dysregulation of the host immune system are all thought to play prominent roles in disease pathogenesis. Additional studies are needed to further explore the clinical and pathophysiological features of CRSwNP so that biomarkers can be identified and novel advances can be made to improve the treatment and management of this disease.
AB - Chronic rhinosinusitis with nasal polyps (CRSwNP) is an important clinical entity diagnosed by the presence of both subjective and objective evidence of chronic sinonasal inflammation. Symptoms include anterior or posterior rhinorrhea, nasal congestion, hyposmia, and/or facial pressure or pain that last for a duration of more than 12 weeks. Nasal polyps are inflammatory lesions that project into the nasal airway, are typically bilateral, and originate from the ethmoid sinus. Males are more likely to be affected than females, but no specific genetic or environmental factors have been strongly linked to the development of this disorder to date. CRSwNP is frequently associated with asthma and allergic rhinitis, but the cellular and molecular mechanisms that contribute to the clinical symptoms are not fully understood. Defects in the sinonasal epithelial cell barrier, increased exposure to pathogenic and colonized bacteria, and dysregulation of the host immune system are all thought to play prominent roles in disease pathogenesis. Additional studies are needed to further explore the clinical and pathophysiological features of CRSwNP so that biomarkers can be identified and novel advances can be made to improve the treatment and management of this disease.
KW - Chronic rhinosinusitis
KW - Chronic rhinosinusitis with nasal polyps
KW - Nasal polyp
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U2 - 10.1016/j.jaip.2016.04.012
DO - 10.1016/j.jaip.2016.04.012
M3 - Article
C2 - 27393770
AN - SCOPUS:85017015996
SN - 2213-2198
VL - 4
SP - 565
EP - 572
JO - Journal of Allergy and Clinical Immunology: In Practice
JF - Journal of Allergy and Clinical Immunology: In Practice
IS - 4
ER -