Chronic Traumatic Encephalopathy Pathology After Shotgun Injury to the Brain

Taylor Tribett, Brittany Erskine, Kristi Bailey, Theodore Brown, Rudy J. Castellani*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


Chronic traumatic encephalopathy (CTE) was initially conceptualized in boxers, but has extended to other athletes in recent years, albeit with limited clinical correlations. It is often asserted that CTE pathology represents the substrate for progressive neurodegenerative disease. We report the case of a shotgun injury to the brain with 42-year survival and no neurological disease progression until shortly before death. The decedent had no other traumatic brain injury (TBI) exposure and did not play football or other high energy collision sport. Neuropathological examination confirmed tissue damage, but additionally demonstrated localized patterns of phosphorylated tau (p-tau) meeting criteria for CTE pathology. P-tau and TDP-43 deposits within marginal tissue of damaged brain were also present focally. No amyloid-β (Aβ) deposits were present. These findings indicate that CTE pathology may occur following a single, severe TBI.

Original languageEnglish (US)
Pages (from-to)1248-1252
Number of pages5
JournalJournal of Forensic Sciences
Issue number4
StatePublished - Jul 2019


  • autopsy
  • chronic traumatic encephalopathy
  • forensic science
  • penetrating traumatic brain injury
  • phosphorylated tau
  • shotgun injury
  • TDP-43

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Genetics


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