Chronopharmacology of anti-convulsive therapy

Sriram Ramgopal, Sigride Thome-Souza, Tobias Loddenkemper*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

32 Scopus citations

Abstract

Approximately one-third of patients with epilepsy continue to have seizures despite antiepileptic therapy. Many seizures occur in diurnal, sleep/wake, circadian, or even monthly patterns. The relationship between biomarkers and state changes is still being investigated, but early results suggest that some of these patterns may be related to endogenous circadian patterns whereas others may be related to wakefulness and sleep or both. Chronotherapy, the application of treatment at times of greatest seizure susceptibility, is a technique that may optimize seizure control in selected patients. It may be used in the form of differential dosing, as preparations designed to deliver sustained or pulsatile drug delivery or in the form of 'zeitgebers' that shift endogenous rhythms. Early trials in epilepsy suggest that chronopharma-cology may provide improved seizure control compared with conventional treatment in some patients. The present article reviews chronopharmacology in the treatment of epilepsy as well as future treatment avenues

Original languageEnglish (US)
Article number339
JournalCurrent neurology and neuroscience reports
Volume13
Issue number4
DOIs
StatePublished - Apr 2013

Keywords

  • Chronopharmacodynamics
  • Chronopharmacokinetics
  • Chronopharmacology
  • Chronotherapy
  • Circadian pattern
  • Circadian rhythms
  • Closedloops
  • DLMO
  • Differential dosing
  • Dimlight melatonin onset
  • Diurnal patterns
  • Epilepsy
  • Lighttherapy
  • Melatonin
  • Pharmacodynamics
  • Pharmacokinetics
  • Seizure diary
  • Seizure patterns
  • Seizures
  • Seizuretracking
  • Suprachiasmatic nucleus

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology

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