Cilia in vertebrate development and disease

Edwin C. Oh, Elias Nicholas Katsanis

Research output: Contribution to journalArticlepeer-review

125 Scopus citations

Abstract

Through the combined study of model organisms, cell biology, cell signaling and medical genetics we have significantly increased our understanding of the structure and functions of the vertebrate cilium. This ancient organelle has now emerged as a crucial component of certain signaling and sensory perception pathways in both developmental and homeostatic contexts. Here, we provide a snapshot of the structure, function and distribution of the vertebrate cilium and of the pathologies that are associated with its dysfunction.

Original languageEnglish (US)
Pages (from-to)443-448
Number of pages6
JournalDevelopment
Volume139
Issue number3
DOIs
StatePublished - Feb 1 2012

Keywords

  • Cilia
  • IFT
  • Signaling

ASJC Scopus subject areas

  • Molecular Biology
  • Developmental Biology

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