Cilia in vertebrate development and disease

Edwin C. Oh; Elias Nicholas Katsanis

doi:10.1242/dev.050054

Cilia in vertebrate development and disease

Edwin C. Oh, Elias Nicholas Katsanis

Pediatrics

Research output: Contribution to journal › Article › peer-review

125 Scopus citations

Abstract

Through the combined study of model organisms, cell biology, cell signaling and medical genetics we have significantly increased our understanding of the structure and functions of the vertebrate cilium. This ancient organelle has now emerged as a crucial component of certain signaling and sensory perception pathways in both developmental and homeostatic contexts. Here, we provide a snapshot of the structure, function and distribution of the vertebrate cilium and of the pathologies that are associated with its dysfunction.

Original language	English (US)
Pages (from-to)	443-448
Number of pages	6
Journal	Development
Volume	139
Issue number	3
DOIs	https://doi.org/10.1242/dev.050054
State	Published - Feb 1 2012

Keywords

Cilia
IFT
Signaling

ASJC Scopus subject areas

Molecular Biology
Developmental Biology

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10.1242/dev.050054

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Cilia in vertebrate development and disease

Abstract

Keywords

ASJC Scopus subject areas

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