Cimetidine and Common Variable Hypogammaglobulinemia

B. K. Wershil, Y. A. Mekori, S. J. Galli

Research output: Contribution to journalLetterpeer-review

5 Scopus citations


To the Editor: The development of effective therapeutic strategies based on in vitro pharmacologic data is fraught with difficulty, and this may be especially true in the case of putative “immunomodulators” such as cimetidine. In their report in the January 24 issue of the Journal,1 White and Ballow review a large body of information establishing that histamine can enhance the activity of suppressor T cells in vitro. Many of these effects can be reversed by cimetidine, an antagonist of H2 receptors. But attempts to use H2 antagonists to influence immunologic responses in vivo have produced conflicting results.

Original languageEnglish (US)
Pages (from-to)264-266
Number of pages3
JournalNew England Journal of Medicine
Issue number4
StatePublished - Jul 25 1985

ASJC Scopus subject areas

  • Medicine(all)


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