Cimetidine-associated thrombocytopenia

H. J. Mann; Joseph R Schneider; J. B. Miller; J. P. Delaney

doi:10.1177/106002808301700209

Cimetidine-associated thrombocytopenia

H. J. Mann, Joseph R Schneider, J. B. Miller, J. P. Delaney

Surgery, Vascular Surgery Division

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

A case of thrombocytopenia associated with cimetidine administration in a 65-year-old white female with recurrent adenocarcinoma is reported. Her platelet count fell from 273,000/mm³ to 35,000/mm³ after cimetidine therapy was started. Upon discontinuation of cimetidine, the platelet count increased to 164,000/mm³. Later in her hospital course, the patient again received cimetidine and her platelet count fell to 37,000/mm³. The patient was never leukopenic during her hospitalization. This is the only reported case of thrombocytopenia in the absence of leukopenia that is documented by a rechallenge with cimetidine.

Original language	English (US)
Pages (from-to)	126-128
Number of pages	3
Journal	Drug Intelligence and Clinical Pharmacy
Volume	17
Issue number	2
DOIs	https://doi.org/10.1177/106002808301700209
State	Published - Jan 1 1983

ASJC Scopus subject areas

Pharmacology, Toxicology and Pharmaceutics(all)
Pharmacology (medical)

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title = "Cimetidine-associated thrombocytopenia",

abstract = "A case of thrombocytopenia associated with cimetidine administration in a 65-year-old white female with recurrent adenocarcinoma is reported. Her platelet count fell from 273,000/mm3 to 35,000/mm3 after cimetidine therapy was started. Upon discontinuation of cimetidine, the platelet count increased to 164,000/mm3. Later in her hospital course, the patient again received cimetidine and her platelet count fell to 37,000/mm3. The patient was never leukopenic during her hospitalization. This is the only reported case of thrombocytopenia in the absence of leukopenia that is documented by a rechallenge with cimetidine.",

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AU - Miller, J. B.

AU - Delaney, J. P.

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N2 - A case of thrombocytopenia associated with cimetidine administration in a 65-year-old white female with recurrent adenocarcinoma is reported. Her platelet count fell from 273,000/mm3 to 35,000/mm3 after cimetidine therapy was started. Upon discontinuation of cimetidine, the platelet count increased to 164,000/mm3. Later in her hospital course, the patient again received cimetidine and her platelet count fell to 37,000/mm3. The patient was never leukopenic during her hospitalization. This is the only reported case of thrombocytopenia in the absence of leukopenia that is documented by a rechallenge with cimetidine.

AB - A case of thrombocytopenia associated with cimetidine administration in a 65-year-old white female with recurrent adenocarcinoma is reported. Her platelet count fell from 273,000/mm3 to 35,000/mm3 after cimetidine therapy was started. Upon discontinuation of cimetidine, the platelet count increased to 164,000/mm3. Later in her hospital course, the patient again received cimetidine and her platelet count fell to 37,000/mm3. The patient was never leukopenic during her hospitalization. This is the only reported case of thrombocytopenia in the absence of leukopenia that is documented by a rechallenge with cimetidine.

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Cimetidine-associated thrombocytopenia

Abstract

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