cIMPACT-NOW: a practical summary of diagnostic points from Round 1 updates

David N. Louis*, David W. Ellison, Daniel J. Brat, Kenneth Aldape, David Capper, Cynthia Hawkins, Werner Paulus, Arie Perry, Guido Reifenberger, Dominique Figarella-Branger, Andreas von Deimling, Pieter Wesseling

*Corresponding author for this work

Research output: Contribution to journalReview article

14 Scopus citations


cIMPACT-NOW (the Consortium to Inform Molecular and Practical Approaches to CNS Tumor Taxonomy) was established to provide a forum to evaluate and recommend proposed changes to future CNS tumor classifications. From 2016 to 2019 (Round 1), cIMPACT published four updates. Update 1 clarified the use of the term NOS (Not Otherwise Specified) and proposed use of the additional term NEC (Not Elsewhere Classified). Update 2 issued clarifications regarding two diagnoses: Diffuse Midline Glioma, H3 K27M-mutant and Diffuse Astrocytoma/Anaplastic Astrocytoma, IDH-mutant. Update 3 proposed molecular criteria that could be used in the setting of an IDH-wildtype diffuse or anaplastic astrocytic glioma without histological features of glioblastoma to infer that the tumor would behave similarly to a grade IV glioblastoma. Update 4 suggested that, in children and young adults, subtypes of IDH-wildtype/H3-wildtype diffuse gliomas may have distinct clinical features in the setting of a BRAFV600E mutation, FGFR1 alteration, other MAPK pathway alteration, or a MYB or MYBL1 rearrangement. The practical diagnostic relevance of these cIMPACT proposals is highlighted in this summary.

Original languageEnglish (US)
Pages (from-to)469-472
Number of pages4
JournalBrain Pathology
Issue number4
StatePublished - Jul 2019

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Neuroscience(all)
  • Clinical Neurology

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    Louis, D. N., Ellison, D. W., Brat, D. J., Aldape, K., Capper, D., Hawkins, C., Paulus, W., Perry, A., Reifenberger, G., Figarella-Branger, D., von Deimling, A., & Wesseling, P. (2019). cIMPACT-NOW: a practical summary of diagnostic points from Round 1 updates. Brain Pathology, 29(4), 469-472.