Abstract
Purpose: To test the hypothesis that cine MRI can be used to characterize features of left and right ventricles in post-capillary pulmonary hypertension (PH) caused by heart failure (HF) with preserved ejection fraction (HFpEF) and HF with reduced ejection fraction (HFrEF). Methods: With the approval of institution review board (IRB), 28 consecutive post-capillary PH patients (11 males, 62.1 ± 13.4 years old, range 39–89 years old) underwent cine MRI scans. Cine MRI-derived left ventricular (LV) ejection fraction (LVEF) and other function, motion, and deformation indices (acquired with heart deformation analysis [HDA]) were compared between PH-HFpEF (defined as LVEF ≥ 50 %]) and PH-HFrEF (LVEF < 50 %) patients and were related with right ventricular (RV) indices and right heart catheterization (RHC)-derived pulmonary artery measurements. Results: Totally 19 patients (68 %, 95 % confident interval [CI] 49 %–86 %) were assigned to PH-HFpEF group while 9 (32 %) was assigned to the PH-HFrEF group. There were differences of LV and right ventricular (RV) global functional indices, LV mass, LV displacement, velocity, strain and strain rate between the two patient groups. Cine MRI-derived LV indices had broad associations with RV indices and RHC measurements. LVEF was negatively correlated with pulmonary capillary wedge pressure (PCWP) (r = -0.5, p = 0.007). LV cardiac index (LVCI) was associated with systolic pulmonary artery pressure (sPAP) (r = 0.443, p = 0.018). Conclusions: PH-HFpEF and PH-HFrEF patients present dissimilar function, motion and deformation features in LV and RV. Cine MRI-derived LV measures are correlated with hemodynamic abnormalities of PH.
Original language | English (US) |
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Article number | 109679 |
Journal | European journal of radiology |
Volume | 139 |
DOIs | |
State | Published - Jun 2021 |
Funding
This study was supported by a grant from Bayer Pharmaceutical . The grant was paid to the institution not to individual researchers. James C. Carr has disclosure: Siemens: research grant to institution; advisory board. Bayer: research grant to institution; advisory board; speaker. Bracco: advisory board. Guerbet: research grant to institution. Other authors have nothing to disclose. This study was partly supported by grants from the National Institute of Health ( K01HL121162 and R03HL144891 to KL).
Keywords
- Cine MRI
- HFpEF
- HFrEF
- Heart deformation analysis
- Post-capillary pulmonary hypertension
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging