TY - JOUR
T1 - Cingulate gyrus neuroanatomy in schizophrenia subjects and their non-psychotic siblings
AU - Calabrese, Daniel R.
AU - Wang, Lei
AU - Harms, Michael P.
AU - Ratnanather, J. Tilak
AU - Barch, Deanna M.
AU - Cloninger, C. Robert
AU - Thompson, Paul A.
AU - Miller, Michael I.
AU - Csernansky, John G.
N1 - Funding Information:
Funding for this study was provided by NIH grants P50 MH071616, R01 MH056584, and P41-RR15241; the NIH had no further role in study design; in the collection, analysis and interpretation of data; in the writing of the report; and in the decision to submit the paper for publication.
PY - 2008/9
Y1 - 2008/9
N2 - Background and methods: In vivo neuroimaging studies have provided evidence of decreases in the gray matter volume of the cingulate gyrus in subjects with schizophrenia as compared to healthy controls. To investigate whether these changes might be related to heritable influences, we used high-resolution magnetic resonance imaging and labeled cortical mantle distance mapping to measure gray matter volume, as well as thickness and the area of the gray/white interface, in the anterior and posterior segments of the cingulate gyrus in 28 subjects with schizophrenia and their non-psychotic siblings, and in 38 healthy control subjects and their siblings. Results: There was a significant effect of group status on posterior cingulate cortex (PCC) gray matter volume (p = 0.02). Subjects with schizophrenia and their non-psychotic siblings showed similar reductions of gray matter volume (~ 10%) in the PCC compared to healthy control subjects and their siblings. In turn, trend level effects of group status were found for thickness (p = 0.08) and surface area (p = 0.11) of the PCC. In the combined group of schizophrenia subjects and their siblings, a direct correlation was observed between PCC gray matter volume and negative symptoms. However, the reduction in PCC gray matter volume in schizophrenia subjects and their siblings was proportionate to an overall reduction in whole cerebral volume, i.e., the effect of group on the volume of the PCC became non-significant when cerebral volume was included as a covariate (p = 0.4). There was no significant effect of group on anterior cingulate cortex volume, thickness, or area. Conclusions: Our findings suggest that decreases in the gray matter volume of the PCC occur in schizophrenia subjects and their siblings. The presence of such decreases in the non-psychotic siblings of schizophrenia subjects suggests that heritable factors may be involved in the development of cortical abnormalities in schizophrenia.
AB - Background and methods: In vivo neuroimaging studies have provided evidence of decreases in the gray matter volume of the cingulate gyrus in subjects with schizophrenia as compared to healthy controls. To investigate whether these changes might be related to heritable influences, we used high-resolution magnetic resonance imaging and labeled cortical mantle distance mapping to measure gray matter volume, as well as thickness and the area of the gray/white interface, in the anterior and posterior segments of the cingulate gyrus in 28 subjects with schizophrenia and their non-psychotic siblings, and in 38 healthy control subjects and their siblings. Results: There was a significant effect of group status on posterior cingulate cortex (PCC) gray matter volume (p = 0.02). Subjects with schizophrenia and their non-psychotic siblings showed similar reductions of gray matter volume (~ 10%) in the PCC compared to healthy control subjects and their siblings. In turn, trend level effects of group status were found for thickness (p = 0.08) and surface area (p = 0.11) of the PCC. In the combined group of schizophrenia subjects and their siblings, a direct correlation was observed between PCC gray matter volume and negative symptoms. However, the reduction in PCC gray matter volume in schizophrenia subjects and their siblings was proportionate to an overall reduction in whole cerebral volume, i.e., the effect of group on the volume of the PCC became non-significant when cerebral volume was included as a covariate (p = 0.4). There was no significant effect of group on anterior cingulate cortex volume, thickness, or area. Conclusions: Our findings suggest that decreases in the gray matter volume of the PCC occur in schizophrenia subjects and their siblings. The presence of such decreases in the non-psychotic siblings of schizophrenia subjects suggests that heritable factors may be involved in the development of cortical abnormalities in schizophrenia.
KW - Cingulated
KW - Cortex
KW - Depth mapping
KW - Schizophrenia
KW - Sibling
KW - Thickness
KW - Volume
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UR - http://www.scopus.com/inward/citedby.url?scp=50249095073&partnerID=8YFLogxK
U2 - 10.1016/j.schres.2008.06.014
DO - 10.1016/j.schres.2008.06.014
M3 - Article
C2 - 18692994
AN - SCOPUS:50249095073
SN - 0920-9964
VL - 104
SP - 61
EP - 70
JO - Schizophrenia Research
JF - Schizophrenia Research
IS - 1-3
ER -
