Circadian clocks and metabolism.

Biliana Marcheva*, Kathryn M. Ramsey, Clara B. Peek, Alison Affinati, Eleonore Maury, Joseph Bass

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review


Circadian clocks maintain periodicity in internal cycles of behavior, physiology, and metabolism, enabling organisms to anticipate the 24-h rotation of the Earth. In mammals, circadian integration of metabolic systems optimizes energy harvesting and utilization across the light/dark cycle. Disruption of clock genes has recently been linked to sleep disorders and to the development of cardiometabolic disease. Conversely, aberrant nutrient signaling affects circadian rhythms of behavior. This chapter reviews the emerging relationship between the molecular clock and metabolic systems and examines evidence that circadian disruption exerts deleterious consequences on human health.

Original languageEnglish (US)
Pages (from-to)127-155
Number of pages29
JournalHandbook of Experimental Pharmacology
Issue number217
StatePublished - Jul 26 2013

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Biochemistry

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