Circadian clocks and metabolism

Biliana Marcheva; Kathryn M. Ramsey; Clara B. Peek; Alison Affinati; Eleonore Maury; Joseph Bass

doi:10.1007/978-3-642-25950-0_6

Circadian clocks and metabolism

Biliana Marcheva, Kathryn M. Ramsey, Clara B. Peek, Alison Affinati, Eleonore Maury, Joseph Bass^*

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Chapter

194 Scopus citations

Abstract

Circadian clocks maintain periodicity in internal cycles of behavior, physiology, and metabolism, enabling organisms to anticipate the 24-h rotation of the Earth. In mammals, circadian integration of metabolic systems optimizes energy harvesting and utilization across the light/dark cycle. Disruption of clock genes has recently been linked to sleep disorders and to the development of cardiometabolic disease. Conversely, aberrant nutrient signaling affects circadian rhythms of behavior. This chapter reviews the emerging relationship between the molecular clock and metabolic systems and examines evidence that circadian disruption exerts deleterious consequences on human health.

Original language	English (US)
Title of host publication	Circadian Clocks
Publisher	Springer Science and Business Media, LLC
Pages	127-155
Number of pages	29
ISBN (Print)	9783642259494
DOIs	https://doi.org/10.1007/978-3-642-25950-0_6
State	Published - 2013

Publication series

Name	Handbook of Experimental Pharmacology
Volume	217
ISSN (Print)	0171-2004
ISSN (Electronic)	1865-0325

Funding

C.B. Peek, A. Affinati and B. Marcheva are supported by NIH grants F32 DK092034-01, 1F30DK085936-01A1, and T32 DK007169, respectively. J. Bass is supported by NIH grants R01 HL097817-01, R01 DK090625-01A1, and P01 AG011412, the American Diabetes Association, the Chicago Biomedical Consortium Searle Funds, and the University of Chicago Diabetes Research and Training Center (grant P60 DK020595).

Keywords

Circadian clock
Energy homeostasis
Metabolic disease
Metabolism
Nutrient sensing

ASJC Scopus subject areas

Biochemistry
General Pharmacology, Toxicology and Pharmaceutics

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1007/978-3-642-25950-0_6

Cite this

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abstract = "Circadian clocks maintain periodicity in internal cycles of behavior, physiology, and metabolism, enabling organisms to anticipate the 24-h rotation of the Earth. In mammals, circadian integration of metabolic systems optimizes energy harvesting and utilization across the light/dark cycle. Disruption of clock genes has recently been linked to sleep disorders and to the development of cardiometabolic disease. Conversely, aberrant nutrient signaling affects circadian rhythms of behavior. This chapter reviews the emerging relationship between the molecular clock and metabolic systems and examines evidence that circadian disruption exerts deleterious consequences on human health.",

keywords = "Circadian clock, Energy homeostasis, Metabolic disease, Metabolism, Nutrient sensing",

author = "Biliana Marcheva and Ramsey, {Kathryn M.} and Peek, {Clara B.} and Alison Affinati and Eleonore Maury and Joseph Bass",

note = "Funding Information: C.B. Peek, A. Affinati and B. Marcheva are supported by NIH grants F32 DK092034-01, 1F30DK085936-01A1, and T32 DK007169, respectively. J. Bass is supported by NIH grants R01 HL097817-01, R01 DK090625-01A1, and P01 AG011412, the American Diabetes Association, the Chicago Biomedical Consortium Searle Funds, and the University of Chicago Diabetes Research and Training Center (grant P60 DK020595). ",

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T1 - Circadian clocks and metabolism

AU - Marcheva, Biliana

AU - Ramsey, Kathryn M.

AU - Peek, Clara B.

AU - Affinati, Alison

AU - Maury, Eleonore

AU - Bass, Joseph

N1 - Funding Information: C.B. Peek, A. Affinati and B. Marcheva are supported by NIH grants F32 DK092034-01, 1F30DK085936-01A1, and T32 DK007169, respectively. J. Bass is supported by NIH grants R01 HL097817-01, R01 DK090625-01A1, and P01 AG011412, the American Diabetes Association, the Chicago Biomedical Consortium Searle Funds, and the University of Chicago Diabetes Research and Training Center (grant P60 DK020595).

PY - 2013

Y1 - 2013

N2 - Circadian clocks maintain periodicity in internal cycles of behavior, physiology, and metabolism, enabling organisms to anticipate the 24-h rotation of the Earth. In mammals, circadian integration of metabolic systems optimizes energy harvesting and utilization across the light/dark cycle. Disruption of clock genes has recently been linked to sleep disorders and to the development of cardiometabolic disease. Conversely, aberrant nutrient signaling affects circadian rhythms of behavior. This chapter reviews the emerging relationship between the molecular clock and metabolic systems and examines evidence that circadian disruption exerts deleterious consequences on human health.

AB - Circadian clocks maintain periodicity in internal cycles of behavior, physiology, and metabolism, enabling organisms to anticipate the 24-h rotation of the Earth. In mammals, circadian integration of metabolic systems optimizes energy harvesting and utilization across the light/dark cycle. Disruption of clock genes has recently been linked to sleep disorders and to the development of cardiometabolic disease. Conversely, aberrant nutrient signaling affects circadian rhythms of behavior. This chapter reviews the emerging relationship between the molecular clock and metabolic systems and examines evidence that circadian disruption exerts deleterious consequences on human health.

KW - Circadian clock

KW - Energy homeostasis

KW - Metabolic disease

KW - Metabolism

KW - Nutrient sensing

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M3 - Chapter

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AN - SCOPUS:84880026907

SN - 9783642259494

T3 - Handbook of Experimental Pharmacology

SP - 127

EP - 155

BT - Circadian Clocks

PB - Springer Science and Business Media, LLC

ER -

Circadian clocks and metabolism

Abstract

Publication series

Funding

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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