Circadian clocks and metabolism

Biliana Marcheva, Kathryn M. Ramsey, Clara B. Peek, Alison Affinati, Eleonore Maury, Joseph Bass*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

177 Scopus citations


Circadian clocks maintain periodicity in internal cycles of behavior, physiology, and metabolism, enabling organisms to anticipate the 24-h rotation of the Earth. In mammals, circadian integration of metabolic systems optimizes energy harvesting and utilization across the light/dark cycle. Disruption of clock genes has recently been linked to sleep disorders and to the development of cardiometabolic disease. Conversely, aberrant nutrient signaling affects circadian rhythms of behavior. This chapter reviews the emerging relationship between the molecular clock and metabolic systems and examines evidence that circadian disruption exerts deleterious consequences on human health.

Original languageEnglish (US)
Title of host publicationCircadian Clocks
PublisherSpringer Science and Business Media, LLC
Number of pages29
ISBN (Print)9783642259494
StatePublished - 2013

Publication series

NameHandbook of Experimental Pharmacology
ISSN (Print)0171-2004
ISSN (Electronic)1865-0325


  • Circadian clock
  • Energy homeostasis
  • Metabolic disease
  • Metabolism
  • Nutrient sensing

ASJC Scopus subject areas

  • Biochemistry
  • Pharmacology, Toxicology and Pharmaceutics(all)


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