Circadian disruption and metabolic disease: Findings from animal models

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152 Scopus citations

Abstract

Social opportunities and work demands have caused humans to become increasingly active during the late evening hours, leading to a shift from the predominantly diurnal lifestyle of our ancestors to a more nocturnal one. This voluntarily decision to stay awake long into the evening hours leads to circadian disruption at the system, tissue, and cellular levels. These derangements are in turn associated with clinical impairments in metabolic processes and physiology. The use of animal models for circadian disruption provides an important opportunity to determine mechanisms by which disorganization in the circadian system can lead to metabolic dysfunction in response to genetic, environmental, and behavioral perturbations. Here we review recent key animal studies involving circadian disruption and discuss the possible translational implications of these studies for human health and particularly for the development of metabolic disease.

Original languageEnglish (US)
Pages (from-to)785-800
Number of pages16
JournalBest Practice and Research: Clinical Endocrinology and Metabolism
Volume24
Issue number5
DOIs
StatePublished - Oct 1 2010

Funding

The present study was supported by NIH/NI A (grant P01 AG11412 ) and NIH/NHLBI (grant 2T32HL007909-11 ). These sponsors were not involved in the collection, analysis, or interpretation of the data or literature. The authors wish to thank Dr. M.H. Vitaterna for her collaboration and Ms. C. Goldschmidt for her technical help with our studies reported in this chapter as well Mr. K.C. Summa for his help in proof-reading the manuscript.

Keywords

  • cardio-metabolic disease
  • circadian rhythms
  • energy metabolism
  • restricted feeding
  • shift work

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

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