Circadian Disruption Associated with Alzheimer’s Disease

Yumna Saeed, Sabra M. Abbott

Research output: Contribution to journalReview article

Abstract

Alzheimer’s disease (AD) is increasing in prevalence and has a significant impact on caregivers and the healthcare system. One of the many physiologic process affected by AD is the circadian system, with disruption reflected in abnormalities of the sleep-wake cycle. This interaction is bidirectional, with circadian and sleep disruption influencing disease progression. Understanding the bidirectional relationship between AD and circadian disruption may allow for earlier recognition of the potential to develop dementia as well as improved targeted approaches for therapy. Therapies including melatonin and bright light therapy may be advantageous in improving sleep and circadian rhythms and preventing the progression of disease. However, unfortunately, these modalities are not curative, and additional research is needed to improve treatment options for these individuals.

LanguageEnglish (US)
Article number29
JournalCurrent Neurology and Neuroscience Reports
Volume17
Issue number4
DOIs
StatePublished - Apr 1 2017

Fingerprint

Alzheimer Disease
Sleep
Disease Progression
Phototherapy
Melatonin
Circadian Rhythm
Caregivers
Dementia
Therapeutics
Delivery of Health Care
Research

Keywords

  • Alzheimer’s disease
  • Bright light therapy
  • Circadian disruption
  • Melatonin
  • β-Amyloid

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology

Cite this

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abstract = "Alzheimer’s disease (AD) is increasing in prevalence and has a significant impact on caregivers and the healthcare system. One of the many physiologic process affected by AD is the circadian system, with disruption reflected in abnormalities of the sleep-wake cycle. This interaction is bidirectional, with circadian and sleep disruption influencing disease progression. Understanding the bidirectional relationship between AD and circadian disruption may allow for earlier recognition of the potential to develop dementia as well as improved targeted approaches for therapy. Therapies including melatonin and bright light therapy may be advantageous in improving sleep and circadian rhythms and preventing the progression of disease. However, unfortunately, these modalities are not curative, and additional research is needed to improve treatment options for these individuals.",
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Circadian Disruption Associated with Alzheimer’s Disease. / Saeed, Yumna; Abbott, Sabra M.

In: Current Neurology and Neuroscience Reports, Vol. 17, No. 4, 29, 01.04.2017.

Research output: Contribution to journalReview article

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AU - Saeed,Yumna

AU - Abbott,Sabra M.

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