Circadian disruption in the pathogenesis of metabolic syndrome

E. Maury*, Hee-kyung Hong, Joseph Bass

*Corresponding author for this work

Research output: Contribution to journalReview article

71 Scopus citations

Abstract

Metabolic syndrome is a multifactorial process induced by a combination of genetic and environmental factors and recent evidence has highlighted that circadian disruption and sleep loss contribute to disease pathogenesis. Emerging work in experimental genetic models has provided insight into the mechanistic basis for clock disruption in disease. Indeed, disruption of the clock system perturbs both neuroendocrine pathways within the hypothalamus important in feeding and energetics, in addition to peripheral tissues involved in glucose and lipid metabolism. This review illustrates the impact of molecular clock disruptions at the level of both brain and behavior and peripheral tissues, with a focus on how such dysregulation in turn impacts lipid and glucose homeostasis, inflammation and cardiovascular function. New insight into circadian biology may ultimately lead to improved therapeutics for metabolic syndrome and cardiovascular disease in humans.

Original languageEnglish (US)
Pages (from-to)338-346
Number of pages9
JournalDiabetes and Metabolism
Volume40
Issue number5
DOIs
StatePublished - Nov 1 2014

Keywords

  • Cardiovascular disease
  • Circadian rhythm
  • Metabolism

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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