Abstract
Metabolic syndrome is a multifactorial process induced by a combination of genetic and environmental factors and recent evidence has highlighted that circadian disruption and sleep loss contribute to disease pathogenesis. Emerging work in experimental genetic models has provided insight into the mechanistic basis for clock disruption in disease. Indeed, disruption of the clock system perturbs both neuroendocrine pathways within the hypothalamus important in feeding and energetics, in addition to peripheral tissues involved in glucose and lipid metabolism. This review illustrates the impact of molecular clock disruptions at the level of both brain and behavior and peripheral tissues, with a focus on how such dysregulation in turn impacts lipid and glucose homeostasis, inflammation and cardiovascular function. New insight into circadian biology may ultimately lead to improved therapeutics for metabolic syndrome and cardiovascular disease in humans.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 338-346 |
| Number of pages | 9 |
| Journal | Diabetes and Metabolism |
| Volume | 40 |
| Issue number | 5 |
| DOIs | |
| State | Published - Nov 1 2014 |
Funding
We thank members of the Bass, Takahashi, Turek and Allada laboratories for helpful discussions. Funding: This work was supported by Alfediam (to E.M.), NIH (P01 AG011412 and R01HL097817-01 to J.B.), American Diabetes Association (to J.B.), Chicago Biomedical Consortium Searle Funds (to J.B.), Juvenile Diabetes Research Foundation (to J.B.), and the University of Chicago Diabetes Research and Training Center (P60 DK020595).
Keywords
- Cardiovascular disease
- Circadian rhythm
- Metabolism
ASJC Scopus subject areas
- Endocrinology
- Internal Medicine
- Endocrinology, Diabetes and Metabolism
