Circadian genes and the sleep-wake cycle

A. D. Laposky*, F. W. Turek

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations


The regulation of virtually all behavioral, physiological, and molecular processes is influenced by whether an organism is asleep or awake. One of the defining characteristics of sleep and wakefulness is that these states are under strong circadian regulation. Rapid advances have been made in discovering and characterizing the genes that make up the molecular circadian clock. These genes are important in directing the timing of sleep and wakefulness, arguably the master output rhythm of the circadian clock. Surprisingly, clock genes have been found to exert more wide-ranging effects on sleep regulation and serve a role in modulating sleep-wake amount, sleep architecture, and the homeostatic response to sleep deprivation. Circadian clock genes have emerged as important genetic components in multiple aspects of sleep and wake regulation.

Original languageEnglish (US)
Title of host publicationEncyclopedia of Neuroscience
PublisherElsevier Ltd
Number of pages6
ISBN (Print)9780080450469
StatePublished - Jan 1 2009


  • Bmal1
  • Circadian clock genes
  • Circadian rhythms
  • Clock
  • Cryptochrome
  • Diurnal rhythms
  • Mammalian clock genes
  • Npas2
  • Period
  • Sleep
  • Sleep homeostasis
  • Suprachiasmatic nucleus

ASJC Scopus subject areas

  • Neuroscience(all)


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