Circadian integration of metabolism and energetics

Joseph Bass*, Joseph S. Takahashi

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

1064 Scopus citations

Abstract

Circadian clocks align behavioral and biochemical processes with the day/night cycle. Nearly all vertebrate cells possess self-sustained clocks that couple endogenous rhythms with changes in cellular environment. Genetic disruption of clock genes in mice perturbs metabolic functions of specific tissues at distinct phases of the sleep/wake cycle. Circadian desynchrony, a characteristic of shift work and sleep disruption in humans, also leads to metabolic pathologies. Here, we review advances in understanding the interrelationship among circadian disruption, sleep deprivation, obesity, and diabetes and implications for rational therapeutics for these conditions.

Original languageEnglish (US)
Pages (from-to)1349-1354
Number of pages6
JournalScience
Volume330
Issue number6009
DOIs
StatePublished - Dec 3 2010

ASJC Scopus subject areas

  • General

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