Abstract
The circadian clock plays an essential role in coordinating feeding and metabolic rhythms with the light/dark cycle. Disruption of clocks is associated with increased adiposity and metabolic disorders, whereas aligning feeding time with cell-autonomous rhythms in metabolism improves health. Here, we provide a comprehensive overview of recent literature in adipose tissue biology as well as our understanding of molecular mechanisms underlying the circadian regulation of transcription, metabolism, and inflammation in adipose tissue. We highlight recent efforts to uncover the mechanistic links between clocks and adipocyte metabolism, as well as its application to dietary and behavioral interventions to improve health and mitigate obesity.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 454-473 |
| Number of pages | 20 |
| Journal | Genes and Development |
| Volume | 37 |
| Issue number | 11-12 |
| DOIs | |
| State | Published - 2023 |
Funding
We thank Biliana Marcheva for illustrations, and Grant Barish, Lisa Beutler, and Clara Bien Peek for helpful discussions. Research support was provided by National Institutes of Health National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) grants R01DK127800, R01DK113011, R01DK090625, R01DK132647, and P30DK020595, and National Institute on Aging (NIA) grants R01AG065988 and P01AG011412 to J.B.; and NIDDK grant F32DK122675 to C.H.
Keywords
- [Keywords: adipocyte
- adipose tissue
- circadian clock
- circadian rhythms
- inflammation
- metabolism
- plasticity]
- thermogenesis
- transcription
ASJC Scopus subject areas
- General Medicine
