Circadian NAD(P)(H) cycles in cell metabolism

Daniel C. Levine, Kathryn M. Ramsey, Joseph Bass*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

8 Scopus citations


Intrinsic circadian clocks are present in all forms of photosensitive life, enabling daily anticipation of the light/dark cycle and separation of energy storage and utilization cycles on a 24-h timescale. The core mechanism underlying circadian rhythmicity involves a cell-autonomous transcription/translation feedback loop that in turn drives rhythmic organismal physiology. In mammals, genetic studies have established that the core clock plays an essential role in maintaining metabolic health through actions within both brain pacemaker neurons and peripheral tissues and that disruption of the clock contributes to disease. Peripheral clocks, in turn, can be entrained by metabolic cues. In this review, we focus on the role of the nucleotide NAD(P)(H) and NAD+-dependent sirtuin deacetylases as integrators of circadian and metabolic cycles, as well as the implications for this interrelationship in healthful aging.

Original languageEnglish (US)
Pages (from-to)15-26
Number of pages12
JournalSeminars in Cell and Developmental Biology
StatePublished - Jun 2022


  • Aging
  • Circadian clock
  • Metabolism
  • Nicotinamide adenine dinucleotide (NAD)
  • Sirtuins

ASJC Scopus subject areas

  • Cell Biology
  • Developmental Biology


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