Circadian Organization

F. W. Turek*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter


Age-related changes in the circadian clock system may underlie various mental and physical disorders. Such changes could occur at many levels of circadian organization, including the input and output pathways to and from the central circadian clock located in the hypothalamic suprachiasmatic nucleus (SCN), as well as within the SCN itself. The recent discovery that most cells/tissues of the body contain the core molecular circadian clock, and regulate the diurnal expression of hundreds of clock-controlled genes, raises fundamental questions about aging of circadian timing systems at tissue and organ levels, both in the central nervous system and in the periphery. While aging can clearly disrupt circadian timing, chronic disruption of circadian timing may lead to an earlier occurrence of aging and age-related diseases.

Original languageEnglish (US)
Title of host publicationEncyclopedia of Neuroscience
PublisherElsevier Ltd
Number of pages6
ISBN (Print)9780080450469
StatePublished - Jan 1 2009


  • Aging
  • Biological clocks
  • Circadian
  • Clock genes
  • Depression
  • Diurnal
  • Entrainment
  • Insomnia
  • Light therapy
  • Melatonin
  • Photoreceptor
  • Rhythms
  • Serotonin
  • Shift work
  • Suprachiasmatic nucleus

ASJC Scopus subject areas

  • Neuroscience(all)


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