Circadian organization of behavior and physiology in Drosophila

Ravi Allada*, Brian Y. Chung

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

333 Scopus citations


Circadian clocks organize behavior and physiology to adapt to daily environmental cycles. Genetic approaches in the fruit fly, Drosophila melanogaster, have revealed widely conserved molecular gears of these 24-h timers. Yet much less is known about how these cell-autonomous clocks confer temporal information to modulate cellular functions. Here we discuss our current knowledge of circadian clock function in Drosophila, providing an overview of the molecular underpinnings of circadian clocks. We then describe the neural network important for circadian rhythms of locomotor activity, including how these molecular clocks might influence neuronal function. Finally, we address a range of behaviors and physiological systems regulated by circadian clocks, including discussion of specific peripheral oscillators and key molecular effectors where they have been described. These studies reveal a remarkable complexity to circadian pathways in this "simple" model organism.

Original languageEnglish (US)
Pages (from-to)605-624
Number of pages20
JournalAnnual review of physiology
StatePublished - Mar 17 2009


  • Feeding
  • Locomotor activity
  • Mating
  • Pacemaker neurons
  • Peripheral clocks

ASJC Scopus subject areas

  • Physiology


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