Circadian rhythm: A natural, robust, multi-scale control system

Francis J. Doyle*, Rudiyanto Gunawan, Neda Bagheri, Henry Mirsky, Tsz Leung To

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

19 Scopus citations


The regulatory architecture responsible for robust maintenance of 24 h cycles is analyzed as a control system. At the gene regulatory level, it is shown that performance attributes, notably phase timing, are controlled in a robust manner. At the next level in the hierarchy, it is shown that synchrony is achieved in populations of neurons to enable clock precision. Finally, at the level of the organism, it is shown that an optimal control approach can be used to reset the clock using a light stimulus.

Original languageEnglish (US)
Pages (from-to)1700-1711
Number of pages12
JournalComputers and Chemical Engineering
Issue number10-12
StatePublished - Sep 12 2006


  • Circadian rhythm
  • Gene regulation
  • Robustness
  • Systems biology

ASJC Scopus subject areas

  • General Chemical Engineering
  • Computer Science Applications


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