Circadian rhythm: A natural, robust, multi-scale control system

Francis J. Doyle; Rudiyanto Gunawan; Neda Bagheri; Henry Mirsky; Tsz Leung To

doi:10.1016/j.compchemeng.2006.05.029

Circadian rhythm: A natural, robust, multi-scale control system

Francis J. Doyle^*, Rudiyanto Gunawan, Neda Bagheri, Henry Mirsky, Tsz Leung To

^*Corresponding author for this work

Chemical and Biological Engineering

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

The regulatory architecture responsible for robust maintenance of 24 h cycles is analyzed as a control system. At the gene regulatory level, it is shown that performance attributes, notably phase timing, are controlled in a robust manner. At the next level in the hierarchy, it is shown that synchrony is achieved in populations of neurons to enable clock precision. Finally, at the level of the organism, it is shown that an optimal control approach can be used to reset the clock using a light stimulus.

Original language	English (US)
Pages (from-to)	1700-1711
Number of pages	12
Journal	Computers and Chemical Engineering
Volume	30
Issue number	10-12
DOIs	https://doi.org/10.1016/j.compchemeng.2006.05.029
State	Published - Sep 12 2006

Keywords

Circadian rhythm
Gene regulation
Robustness
Systems biology

ASJC Scopus subject areas

General Chemical Engineering
Computer Science Applications

Access to Document

10.1016/j.compchemeng.2006.05.029

Cite this

@article{ac1f567bc71d48a0834778e4a6cd6d53,

title = "Circadian rhythm: A natural, robust, multi-scale control system",

abstract = "The regulatory architecture responsible for robust maintenance of 24 h cycles is analyzed as a control system. At the gene regulatory level, it is shown that performance attributes, notably phase timing, are controlled in a robust manner. At the next level in the hierarchy, it is shown that synchrony is achieved in populations of neurons to enable clock precision. Finally, at the level of the organism, it is shown that an optimal control approach can be used to reset the clock using a light stimulus.",

keywords = "Circadian rhythm, Gene regulation, Robustness, Systems biology",

author = "Doyle, {Francis J.} and Rudiyanto Gunawan and Neda Bagheri and Henry Mirsky and To, {Tsz Leung}",

note = "Funding Information: Sections of this manuscript describe projects that are ongoing collaborations of FJD with the following individuals: J{\"o}rg Stelling (ETH), Mike Henson (U. Massachusetts), Erik Herzog (Washington U.), and Linda Petzold (UCSB)—their intellectual contributions are greatly appreciated. This work has been supported by research funds from DARPA, the Air Force Office of Scientific Research, and by the Institute for Collaborative Biotechnologies through grant DAAD19-03-D-0004 from the U.S. Army Research Office. ",

year = "2006",

month = sep,

day = "12",

doi = "10.1016/j.compchemeng.2006.05.029",

language = "English (US)",

volume = "30",

pages = "1700--1711",

journal = "Computers and Chemical Engineering",

issn = "0098-1354",

publisher = "Elsevier B.V.",

number = "10-12",

}

TY - JOUR

T1 - Circadian rhythm

T2 - A natural, robust, multi-scale control system

AU - Doyle, Francis J.

AU - Gunawan, Rudiyanto

AU - Bagheri, Neda

AU - Mirsky, Henry

AU - To, Tsz Leung

N1 - Funding Information: Sections of this manuscript describe projects that are ongoing collaborations of FJD with the following individuals: Jörg Stelling (ETH), Mike Henson (U. Massachusetts), Erik Herzog (Washington U.), and Linda Petzold (UCSB)—their intellectual contributions are greatly appreciated. This work has been supported by research funds from DARPA, the Air Force Office of Scientific Research, and by the Institute for Collaborative Biotechnologies through grant DAAD19-03-D-0004 from the U.S. Army Research Office.

PY - 2006/9/12

Y1 - 2006/9/12

N2 - The regulatory architecture responsible for robust maintenance of 24 h cycles is analyzed as a control system. At the gene regulatory level, it is shown that performance attributes, notably phase timing, are controlled in a robust manner. At the next level in the hierarchy, it is shown that synchrony is achieved in populations of neurons to enable clock precision. Finally, at the level of the organism, it is shown that an optimal control approach can be used to reset the clock using a light stimulus.

AB - The regulatory architecture responsible for robust maintenance of 24 h cycles is analyzed as a control system. At the gene regulatory level, it is shown that performance attributes, notably phase timing, are controlled in a robust manner. At the next level in the hierarchy, it is shown that synchrony is achieved in populations of neurons to enable clock precision. Finally, at the level of the organism, it is shown that an optimal control approach can be used to reset the clock using a light stimulus.

KW - Circadian rhythm

KW - Gene regulation

KW - Robustness

KW - Systems biology

UR - http://www.scopus.com/inward/record.url?scp=33747894288&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33747894288&partnerID=8YFLogxK

U2 - 10.1016/j.compchemeng.2006.05.029

DO - 10.1016/j.compchemeng.2006.05.029

M3 - Article

AN - SCOPUS:33747894288

SN - 0098-1354

VL - 30

SP - 1700

EP - 1711

JO - Computers and Chemical Engineering

JF - Computers and Chemical Engineering

IS - 10-12

ER -

Circadian rhythm: A natural, robust, multi-scale control system

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this