Circadian Rhythm Sleep Disorders

Lirong Zhu; Phyllis C. Zee

doi:10.1016/j.ncl.2012.08.011

Circadian Rhythm Sleep Disorders

Lirong Zhu, Phyllis C. Zee^*

^*Corresponding author for this work

Neurology

Research output: Contribution to journal › Review article › peer-review

96 Scopus citations

Abstract

There have been remarkable advances in our understanding of the molecular, cellular, and physiologic mechanisms underlying the regulation of circadian rhythms, and of the impact of circadian dysfunction on health and disease. This information has transformed our understanding of the effect of circadian rhythm sleep disorders (CRSD) on health, performance, and safety. CRSDs are caused by alterations of the central circadian timekeeping system, or a misalignment of the endogenous circadian rhythm and the external environment. This article reviews circadian biology and discusses the pathophysiology, clinical features, diagnosis, and treatment of the most commonly encountered CRSDs in clinical practice.

Original language	English (US)
Pages (from-to)	1167-1191
Number of pages	25
Journal	Neurologic clinics
Volume	30
Issue number	4
DOIs	https://doi.org/10.1016/j.ncl.2012.08.011
State	Published - Nov 2012

Keywords

Circadian rhythm
Jet lag
Light
Melatonin
Shift work
Sleep phase

ASJC Scopus subject areas

Clinical Neurology

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10.1016/j.ncl.2012.08.011

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title = "Circadian Rhythm Sleep Disorders",

abstract = "There have been remarkable advances in our understanding of the molecular, cellular, and physiologic mechanisms underlying the regulation of circadian rhythms, and of the impact of circadian dysfunction on health and disease. This information has transformed our understanding of the effect of circadian rhythm sleep disorders (CRSD) on health, performance, and safety. CRSDs are caused by alterations of the central circadian timekeeping system, or a misalignment of the endogenous circadian rhythm and the external environment. This article reviews circadian biology and discusses the pathophysiology, clinical features, diagnosis, and treatment of the most commonly encountered CRSDs in clinical practice.",

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author = "Lirong Zhu and Zee, {Phyllis C.}",

year = "2012",

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AU - Zhu, Lirong

AU - Zee, Phyllis C.

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AB - There have been remarkable advances in our understanding of the molecular, cellular, and physiologic mechanisms underlying the regulation of circadian rhythms, and of the impact of circadian dysfunction on health and disease. This information has transformed our understanding of the effect of circadian rhythm sleep disorders (CRSD) on health, performance, and safety. CRSDs are caused by alterations of the central circadian timekeeping system, or a misalignment of the endogenous circadian rhythm and the external environment. This article reviews circadian biology and discusses the pathophysiology, clinical features, diagnosis, and treatment of the most commonly encountered CRSDs in clinical practice.

KW - Circadian rhythm

KW - Jet lag

KW - Light

KW - Melatonin

KW - Shift work

KW - Sleep phase

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JO - Neurologic Clinics

JF - Neurologic Clinics

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ER -

Circadian Rhythm Sleep Disorders

Abstract

Keywords

ASJC Scopus subject areas

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