Circadian Rhythm Sleep Disorders

Lirong Zhu, Phyllis C. Zee*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

96 Scopus citations


There have been remarkable advances in our understanding of the molecular, cellular, and physiologic mechanisms underlying the regulation of circadian rhythms, and of the impact of circadian dysfunction on health and disease. This information has transformed our understanding of the effect of circadian rhythm sleep disorders (CRSD) on health, performance, and safety. CRSDs are caused by alterations of the central circadian timekeeping system, or a misalignment of the endogenous circadian rhythm and the external environment. This article reviews circadian biology and discusses the pathophysiology, clinical features, diagnosis, and treatment of the most commonly encountered CRSDs in clinical practice.

Original languageEnglish (US)
Pages (from-to)1167-1191
Number of pages25
JournalNeurologic clinics
Issue number4
StatePublished - Nov 2012


  • Circadian rhythm
  • Jet lag
  • Light
  • Melatonin
  • Shift work
  • Sleep phase

ASJC Scopus subject areas

  • Clinical Neurology


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