Circadian rhythms and metabolic syndrome: From experimental genetics to human disease

Eleonore Maury, Kathryn Moynihan Ramsey, Joseph Bass*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

303 Scopus citations

Abstract

The incidence of the metabolic syndrome represents a spectrum of disorders that continue to increase across the industrialized world. Both genetic and environmental factors contribute to metabolic syndrome and recent evidence has emerged to suggest that alterations in circadian systems and sleep participate in the pathogenesis of the disease. In this review, we highlight studies at the intersection of clinical medicine and experimental genetics that pinpoint how perturbations of the internal clock system, and sleep, constitute risk factors for disorders including obesity, diabetes mellitus, cardiovascular disease, thrombosis and even inflammation. An exciting aspect of the field has been the integration of behavioral and physiological approaches, and the emerging insight into both neural and peripheral tissues in disease pathogenesis. Consideration of the cell and molecular links between disorders of circadian rhythms and sleep with metabolic syndrome has begun to open new opportunities for mechanism-based therapeutics.

Original languageEnglish (US)
Pages (from-to)447-462
Number of pages16
JournalCirculation research
Volume106
Issue number3
DOIs
StatePublished - Feb 2010

Keywords

  • Circadian
  • Clock
  • Metabolic syndrome

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

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