Circadian rhythms and metabolism: from the brain to the gut and back again

Matthew R. Cribbet, Ryan W. Logan, Mathew D. Edwards, Erin Hanlon, Clara Bien Peek, Jeremy J. Stubblefield, Sridhar Vasudevan, Fiona Ritchey, Ellen Frank*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


This paper focuses on the relationship between the circadian system and glucose metabolism. Research across the translational spectrum confirms the importance of the circadian system for glucose metabolism and offers promising clues as to when and why these systems go awry. In particular, basic research has started to clarify the molecular and genetic mechanisms through which the circadian system regulates metabolism. The study of human behavior, especially in the context of psychiatric disorders, such as bipolar disorder and major depression, forces us to see how inextricably linked mental health and metabolic health are. We also emphasize the remarkable opportunities for advancing circadian science through big data and advanced analytics. Advances in circadian research have translated into environmental and pharmacological interventions with tremendous therapeutic potential.

Original languageEnglish (US)
Pages (from-to)21-40
Number of pages20
JournalAnnals of the New York Academy of Sciences
Issue number1
StatePublished - Dec 1 2016


  • circadian rhythms
  • genetics
  • glucose
  • metabolism
  • mood disorders

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science


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