Circadian Rhythms, Genetics of

F. W. Turek*, M. H. Vitaterna

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Abstract

As with the stress response, the expression of circadian rhythms enables an organism to adapt to changes in the external environment. Of course, the changes in the environment that represent the substrate for the evolution of circadian rhythmicity occur on a relatively predictable basis that coincides with the 24-h rhythms in the external environment due to the rotation of the earth on its axis. Interestingly, many of the metabolic and endocrine events associated with stress also show predictable circadian rhythmicity, indicating that these two adaptive systems are highly integrated with one another. Both systems are under tight genetic control, and this article focuses on (1) the genes underlying the generation of circadian rhythms, (2) the recent evidence that most, if not all, tissues of the body, including those involved in the stress response, contain the molecular circadian clock core machinery, and (3) the evidence that disruption of the molecular clock can lead to tissue and organismal dysfunction. © 2007

Original languageEnglish (US)
Title of host publicationEncyclopedia of Stress
PublisherElsevier Inc
Pages508-512
Number of pages5
ISBN (Print)9780123739476
DOIs
StatePublished - Jan 1 2007

    Fingerprint

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this