Circadian rhythms: Molecular basis of the clock

Lisa D Wilsbacher*, Joseph S. Takahashi

*Corresponding author for this work

Research output: Contribution to journalReview article

67 Citations (Scopus)

Abstract

Much progress has been made during the past year in the molecular dissection of the circadian clock. Recently identified circadian genes in mouse, Drosophila, and cyanobacteria demonstrate the universal nature of negative feedback regulation as a circadian mechanism; furthermore, the mouse and Drosophila genes are structurally and functionally conserved. In addition, the discovery of brain-independent clocks promises to revolutionize the study of circadian biology.

Original languageEnglish (US)
Pages (from-to)595-602
Number of pages8
JournalCurrent Opinion in Genetics and Development
Volume8
Issue number5
DOIs
StatePublished - Jan 1 1998

Fingerprint

Circadian Rhythm
Drosophila
Circadian Clocks
Cyanobacteria
Genes
Dissection
Brain

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology

Cite this

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Circadian rhythms : Molecular basis of the clock. / Wilsbacher, Lisa D; Takahashi, Joseph S.

In: Current Opinion in Genetics and Development, Vol. 8, No. 5, 01.01.1998, p. 595-602.

Research output: Contribution to journalReview article

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T2 - Molecular basis of the clock

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AU - Takahashi, Joseph S.

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AB - Much progress has been made during the past year in the molecular dissection of the circadian clock. Recently identified circadian genes in mouse, Drosophila, and cyanobacteria demonstrate the universal nature of negative feedback regulation as a circadian mechanism; furthermore, the mouse and Drosophila genes are structurally and functionally conserved. In addition, the discovery of brain-independent clocks promises to revolutionize the study of circadian biology.

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