Circadian Rhythms of Heart Rate Variability in Hypertrophic Cardiomyopathy

Stefano Guzzetti*, Lubna Choudhury, Silvia Mezzetti, Chiara Cogliati, Paolo G. Camici, Alberto Malliani

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Background: It has been hypothesized that an interaction between sympathetic nervous activity and an abnormal myocardium plays a role in the development and progression of hypertrophic cardiomyopathy (HCM). Methods: In the present study we investigated cardiac autonomic function by 24-hour spectral analysis of heart rate variability (HRV) in 18 patients with HCM, without evidence of heart failure, and 18 controls of similar age. Results: We found a significant reduction of 24 hour variance in HCM patients relative to controls (15,000 ± 9480 ms2 vs 24,720 ± 12,450 ms2 respectively; p <0.05). Moreover, a loss of the expected day-night changes in the low frequency (LF) spectral component (expressed in normalized units), and LF/HF ratio (HF; high frequency component) were observed in HCM patients. Decreased day-night changes in LF/HF ratio were previously reported in patients with mild hypertension, uncomplicated coronary disease, and after myocardial infarction, conditions in which it seems to exist a higher than normal sympathetic activity. No significant correlations were found between HRV indices and echocardiographic standard measures of systolic and diastolic function parameters. Conclusions: These data are consistent with the presence of an alteration in neural modulation of heart period in HCM patients, noninvasively detectable by continuous 24 hour HRV analysis.

Original languageEnglish (US)
Pages (from-to)349-353
Number of pages5
JournalAnnals of Noninvasive Electrocardiology
Issue number4
StatePublished - Jan 1 1996


  • Heart rate variability
  • Holter monitoring
  • Hypertrophic cardiomyopathy
  • Power spectral analysis
  • Sympathetic excitation

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)


Dive into the research topics of 'Circadian Rhythms of Heart Rate Variability in Hypertrophic Cardiomyopathy'. Together they form a unique fingerprint.

Cite this