Circadian topology of metabolism

Joseph Bass*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

406 Scopus citations

Abstract

Biological clocks are genetically encoded oscillators that allow organisms to anticipate changes in the light-dark environment that are tied to the rotation of Earth. Clocks enhance fitness and growth in prokaryotes, and they are expressed throughout the central nervous system and peripheral tissues of multicelled organisms in which they influence sleep, arousal, feeding and metabolism. Biological clocks capture the imagination because of their tie to geophysical time, and tools are now in hand to analyse their function in health and disease at the cellular and molecular level.

Original languageEnglish (US)
Pages (from-to)348-356
Number of pages9
JournalNature
Volume491
Issue number7424
DOIs
StatePublished - Nov 15 2012

ASJC Scopus subject areas

  • General

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