Circadian Transcription from Beta Cell Function to Diabetes Pathophysiology

Mark Perelis, Kathryn Moynihan Ramsey, Biliana Marcheva, Joseph Bass*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

23 Scopus citations

Abstract

The mammalian circadian clock plays a central role in the temporal coordination of physiology across the 24-h light-dark cycle. A major function of the clock is to maintain energy constancy in anticipation of alternating periods of fasting and feeding that correspond with sleep and wakefulness. While it has long been recognized that humans exhibit robust variation in glucose tolerance and insulin sensitivity across the sleep-wake cycle, experimental genetic analysis has now revealed that the clock transcription cycle plays an essential role in insulin secretion and metabolic function within pancreatic beta cells. This review addresses how studies of the beta cell clock may elucidate the etiology of subtypes of diabetes associated with circadian and sleep cycle disruption, in addition to more general forms of the disease.

Original languageEnglish (US)
Pages (from-to)323-336
Number of pages14
JournalJournal of biological rhythms
Volume31
Issue number4
DOIs
StatePublished - Aug 1 2016

Keywords

  • circadian transcription
  • diabetes
  • genomics
  • mouse genetics
  • pancreatic beta cell

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

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