Circuit activity underlying a distinct modulator of prepulse inhibition

Linda Heidinger; James L. Reilly; Lei Wang; Morris B. Goldman

doi:10.1016/j.pscychresns.2019.04.005

Circuit activity underlying a distinct modulator of prepulse inhibition

Linda Heidinger, James L. Reilly, Lei Wang, Morris B. Goldman^*

^*Corresponding author for this work

Psychiatry and Behavioral Sciences

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Prepulse inhibition (PPI), the diminished eye blink response to a startling pulse induced by a prepulse, is regulated by brainstem, and modulated by cerebral, processes. Attentional modulation by the prepulse (AMP), a potential biomarker of psychotic disorders, differs from other modulatory processes because it only occurs if the interval between the prepulse and pulse exceeds 100 ms (>PP100). Videotaped eye blinks were measured during fMRI scanning in 15 healthy subjects hearing 64 pulse alone, 64 PP60 and 64 PP120 trials in a rapid event-related design. Because attentional influences on PPI vary spontaneously, we posited AMP could be isolated by comparing eye blink and Blood Oxygen Level Dependent covariation during the two PP trial types. Behavioral regressor coefficients reflecting significant covariation covered the insula and auditory cortices during PP120 but not PP60 trials. Clusters within the right anterior insula and auditory cortex were specific to AMP. Functional connections (FCs) between cerebral ROIs implicated in PPI were stronger during PP120 trials. The four FCs that were individually stronger during PP120 trials involved the right insula or auditory cortex and three were not present during PP60 trials. Converging evidence indicates the right insula is the hub of a network underlying AMP.

Original language	English (US)
Pages (from-to)	1-11
Number of pages	11
Journal	Psychiatry Research - Neuroimaging
Volume	288
DOIs	https://doi.org/10.1016/j.pscychresns.2019.04.005
State	Published - Jun 30 2019

Keywords

Attention
Behavioral regressor
Biomarker
Functional MRI
Functional connectivity
Salience
Schizophrenia

ASJC Scopus subject areas

Neuroscience (miscellaneous)
Radiology Nuclear Medicine and imaging
Psychiatry and Mental health

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.pscychresns.2019.04.005

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title = "Circuit activity underlying a distinct modulator of prepulse inhibition",

abstract = "Prepulse inhibition (PPI), the diminished eye blink response to a startling pulse induced by a prepulse, is regulated by brainstem, and modulated by cerebral, processes. Attentional modulation by the prepulse (AMP), a potential biomarker of psychotic disorders, differs from other modulatory processes because it only occurs if the interval between the prepulse and pulse exceeds 100 ms (>PP100). Videotaped eye blinks were measured during fMRI scanning in 15 healthy subjects hearing 64 pulse alone, 64 PP60 and 64 PP120 trials in a rapid event-related design. Because attentional influences on PPI vary spontaneously, we posited AMP could be isolated by comparing eye blink and Blood Oxygen Level Dependent covariation during the two PP trial types. Behavioral regressor coefficients reflecting significant covariation covered the insula and auditory cortices during PP120 but not PP60 trials. Clusters within the right anterior insula and auditory cortex were specific to AMP. Functional connections (FCs) between cerebral ROIs implicated in PPI were stronger during PP120 trials. The four FCs that were individually stronger during PP120 trials involved the right insula or auditory cortex and three were not present during PP60 trials. Converging evidence indicates the right insula is the hub of a network underlying AMP.",

keywords = "Attention, Behavioral regressor, Biomarker, Functional MRI, Functional connectivity, Salience, Schizophrenia",

author = "Linda Heidinger and Reilly, {James L.} and Lei Wang and Goldman, {Morris B.}",

note = "Funding Information: The authors wish to acknowledge the contributions of William Bieth; Brandon Gardner, MD, PhD; Fozia Ghafoor, MD;, PhD; Kirti Kulkarni MD; Sarah Lia Nainggolan MD; Robert Lyons; Donald G. McLaren , PhD; Stephanie Papillon MD; Nicholas Patniyot , MD; Luiz Pessoa PhD; Todd Parrish PhD; Matthew Schroeder PhD; Steve Small, MD, PhD; Mathew Smith, Ph.D. Anna Solodkin PhD; Tommi Raij, MD. PhD.; Xue Wang PhD; Zuoli Zhang, MD; and the staffs of the University of Chicago and Northwestern University imaging centers for this work. Many of the above individuals made sustained and/or essential contributions to the development and success of the study design as well as data collection and analyses. Much of the intellectual backbone of this study was also provided by those listed above. Funding provided by the Brain Research Foundation of the University of Chicago and a NARSAD Independent Investigators Award to MBG. The authors declare they have no conflicts of interest. Publisher Copyright: {\textcopyright} 2019",

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doi = "10.1016/j.pscychresns.2019.04.005",

language = "English (US)",

volume = "288",

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T1 - Circuit activity underlying a distinct modulator of prepulse inhibition

AU - Heidinger, Linda

AU - Reilly, James L.

AU - Wang, Lei

AU - Goldman, Morris B.

N1 - Funding Information: The authors wish to acknowledge the contributions of William Bieth; Brandon Gardner, MD, PhD; Fozia Ghafoor, MD;, PhD; Kirti Kulkarni MD; Sarah Lia Nainggolan MD; Robert Lyons; Donald G. McLaren , PhD; Stephanie Papillon MD; Nicholas Patniyot , MD; Luiz Pessoa PhD; Todd Parrish PhD; Matthew Schroeder PhD; Steve Small, MD, PhD; Mathew Smith, Ph.D. Anna Solodkin PhD; Tommi Raij, MD. PhD.; Xue Wang PhD; Zuoli Zhang, MD; and the staffs of the University of Chicago and Northwestern University imaging centers for this work. Many of the above individuals made sustained and/or essential contributions to the development and success of the study design as well as data collection and analyses. Much of the intellectual backbone of this study was also provided by those listed above. Funding provided by the Brain Research Foundation of the University of Chicago and a NARSAD Independent Investigators Award to MBG. The authors declare they have no conflicts of interest. Publisher Copyright: © 2019

PY - 2019/6/30

Y1 - 2019/6/30

N2 - Prepulse inhibition (PPI), the diminished eye blink response to a startling pulse induced by a prepulse, is regulated by brainstem, and modulated by cerebral, processes. Attentional modulation by the prepulse (AMP), a potential biomarker of psychotic disorders, differs from other modulatory processes because it only occurs if the interval between the prepulse and pulse exceeds 100 ms (>PP100). Videotaped eye blinks were measured during fMRI scanning in 15 healthy subjects hearing 64 pulse alone, 64 PP60 and 64 PP120 trials in a rapid event-related design. Because attentional influences on PPI vary spontaneously, we posited AMP could be isolated by comparing eye blink and Blood Oxygen Level Dependent covariation during the two PP trial types. Behavioral regressor coefficients reflecting significant covariation covered the insula and auditory cortices during PP120 but not PP60 trials. Clusters within the right anterior insula and auditory cortex were specific to AMP. Functional connections (FCs) between cerebral ROIs implicated in PPI were stronger during PP120 trials. The four FCs that were individually stronger during PP120 trials involved the right insula or auditory cortex and three were not present during PP60 trials. Converging evidence indicates the right insula is the hub of a network underlying AMP.

AB - Prepulse inhibition (PPI), the diminished eye blink response to a startling pulse induced by a prepulse, is regulated by brainstem, and modulated by cerebral, processes. Attentional modulation by the prepulse (AMP), a potential biomarker of psychotic disorders, differs from other modulatory processes because it only occurs if the interval between the prepulse and pulse exceeds 100 ms (>PP100). Videotaped eye blinks were measured during fMRI scanning in 15 healthy subjects hearing 64 pulse alone, 64 PP60 and 64 PP120 trials in a rapid event-related design. Because attentional influences on PPI vary spontaneously, we posited AMP could be isolated by comparing eye blink and Blood Oxygen Level Dependent covariation during the two PP trial types. Behavioral regressor coefficients reflecting significant covariation covered the insula and auditory cortices during PP120 but not PP60 trials. Clusters within the right anterior insula and auditory cortex were specific to AMP. Functional connections (FCs) between cerebral ROIs implicated in PPI were stronger during PP120 trials. The four FCs that were individually stronger during PP120 trials involved the right insula or auditory cortex and three were not present during PP60 trials. Converging evidence indicates the right insula is the hub of a network underlying AMP.

KW - Attention

KW - Behavioral regressor

KW - Biomarker

KW - Functional MRI

KW - Functional connectivity

KW - Salience

KW - Schizophrenia

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U2 - 10.1016/j.pscychresns.2019.04.005

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AN - SCOPUS:85066415955

VL - 288

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JO - Psychiatry Research - Neuroimaging

JF - Psychiatry Research - Neuroimaging

SN - 0925-4927

ER -

Circuit activity underlying a distinct modulator of prepulse inhibition

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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