Abstract
Prepulse inhibition (PPI), the diminished eye blink response to a startling pulse induced by a prepulse, is regulated by brainstem, and modulated by cerebral, processes. Attentional modulation by the prepulse (AMP), a potential biomarker of psychotic disorders, differs from other modulatory processes because it only occurs if the interval between the prepulse and pulse exceeds 100 ms (>PP100). Videotaped eye blinks were measured during fMRI scanning in 15 healthy subjects hearing 64 pulse alone, 64 PP60 and 64 PP120 trials in a rapid event-related design. Because attentional influences on PPI vary spontaneously, we posited AMP could be isolated by comparing eye blink and Blood Oxygen Level Dependent covariation during the two PP trial types. Behavioral regressor coefficients reflecting significant covariation covered the insula and auditory cortices during PP120 but not PP60 trials. Clusters within the right anterior insula and auditory cortex were specific to AMP. Functional connections (FCs) between cerebral ROIs implicated in PPI were stronger during PP120 trials. The four FCs that were individually stronger during PP120 trials involved the right insula or auditory cortex and three were not present during PP60 trials. Converging evidence indicates the right insula is the hub of a network underlying AMP.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1-11 |
| Number of pages | 11 |
| Journal | Psychiatry research. Neuroimaging |
| Volume | 288 |
| DOIs | |
| State | Published - Jun 30 2019 |
Fingerprint
Keywords
- Attention
- Behavioral regressor
- Biomarker
- Functional connectivity
- Functional MRI
- Salience
- Schizophrenia
ASJC Scopus subject areas
- Neuroscience (miscellaneous)
- Radiology Nuclear Medicine and imaging
- Psychiatry and Mental health
Cite this
}
Circuit activity underlying a distinct modulator of prepulse inhibition. / Heidinger, Linda; Reilly, James L; Wang, Lei; Goldman, Morris B.
In: Psychiatry research. Neuroimaging, Vol. 288, 30.06.2019, p. 1-11.Research output: Contribution to journal › Article
TY - JOUR
T1 - Circuit activity underlying a distinct modulator of prepulse inhibition
AU - Heidinger, Linda
AU - Reilly, James L
AU - Wang, Lei
AU - Goldman, Morris B
PY - 2019/6/30
Y1 - 2019/6/30
N2 - Prepulse inhibition (PPI), the diminished eye blink response to a startling pulse induced by a prepulse, is regulated by brainstem, and modulated by cerebral, processes. Attentional modulation by the prepulse (AMP), a potential biomarker of psychotic disorders, differs from other modulatory processes because it only occurs if the interval between the prepulse and pulse exceeds 100 ms (>PP100). Videotaped eye blinks were measured during fMRI scanning in 15 healthy subjects hearing 64 pulse alone, 64 PP60 and 64 PP120 trials in a rapid event-related design. Because attentional influences on PPI vary spontaneously, we posited AMP could be isolated by comparing eye blink and Blood Oxygen Level Dependent covariation during the two PP trial types. Behavioral regressor coefficients reflecting significant covariation covered the insula and auditory cortices during PP120 but not PP60 trials. Clusters within the right anterior insula and auditory cortex were specific to AMP. Functional connections (FCs) between cerebral ROIs implicated in PPI were stronger during PP120 trials. The four FCs that were individually stronger during PP120 trials involved the right insula or auditory cortex and three were not present during PP60 trials. Converging evidence indicates the right insula is the hub of a network underlying AMP.
AB - Prepulse inhibition (PPI), the diminished eye blink response to a startling pulse induced by a prepulse, is regulated by brainstem, and modulated by cerebral, processes. Attentional modulation by the prepulse (AMP), a potential biomarker of psychotic disorders, differs from other modulatory processes because it only occurs if the interval between the prepulse and pulse exceeds 100 ms (>PP100). Videotaped eye blinks were measured during fMRI scanning in 15 healthy subjects hearing 64 pulse alone, 64 PP60 and 64 PP120 trials in a rapid event-related design. Because attentional influences on PPI vary spontaneously, we posited AMP could be isolated by comparing eye blink and Blood Oxygen Level Dependent covariation during the two PP trial types. Behavioral regressor coefficients reflecting significant covariation covered the insula and auditory cortices during PP120 but not PP60 trials. Clusters within the right anterior insula and auditory cortex were specific to AMP. Functional connections (FCs) between cerebral ROIs implicated in PPI were stronger during PP120 trials. The four FCs that were individually stronger during PP120 trials involved the right insula or auditory cortex and three were not present during PP60 trials. Converging evidence indicates the right insula is the hub of a network underlying AMP.
KW - Attention
KW - Behavioral regressor
KW - Biomarker
KW - Functional connectivity
KW - Functional MRI
KW - Salience
KW - Schizophrenia
UR - http://www.scopus.com/inward/record.url?scp=85066415955&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85066415955&partnerID=8YFLogxK
U2 - 10.1016/j.pscychresns.2019.04.005
DO - 10.1016/j.pscychresns.2019.04.005
M3 - Article
C2 - 31030001
AN - SCOPUS:85066415955
VL - 288
SP - 1
EP - 11
JO - Psychiatry Research - Neuroimaging
JF - Psychiatry Research - Neuroimaging
SN - 0925-4927
ER -