Circuit Mechanisms of a Retinal Ganglion Cell with Stimulus-Dependent Response Latency and Activation Beyond Its Dendrites

Adam Mani, Gregory William Schwartz*

*Corresponding author for this work

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

Center-surround antagonism has been used as the canonical model to describe receptive fields of retinal ganglion cells (RGCs) for decades. We describe a newly identified RGC type in the mouse, called the ON delayed (OND) RGC, with receptive field properties that deviate from center-surround organization. Responding with an unusually long latency to light stimulation, OND RGCs respond earlier as the visual stimulus increases in size. Furthermore, OND RGCs are excited by light falling far beyond their dendrites. We unravel details of the circuit mechanisms behind these phenomena, revealing new roles for inhibition in controlling both temporal and spatial receptive field properties. The non-canonical receptive field properties of the OND RGC—integration of long temporal and large spatial scales—suggest that unlike typical RGCs, it may encode a slowly varying, global property of the visual scene.

Original languageEnglish (US)
Pages (from-to)471-482
Number of pages12
JournalCurrent Biology
Volume27
Issue number4
DOIs
Publication statusPublished - Feb 20 2017

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Keywords

  • center-surround
  • circuit
  • extra-dendritic
  • ganglion cells
  • image focus
  • latency
  • mouse
  • receptive field
  • retina
  • serial inhibition

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

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